Project 170246
Characterization of the elaborate interplay between HIV-1 and dendritic cells
Characterization of the elaborate interplay between HIV-1 and dendritic cells
Project Information
| Study Type: | Other Basic_Science |
| Therapeutic Area: | Oncology |
| Research Theme: | Biomedical |
| Disease Area: | cancer cell survival mechanisms |
Institution & Funding
| Principal Investigator(s): | Tremblay, Michel J |
| Institution: | Centre hospitalier de l'Université Laval (Québec) |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Virology & Viral Pathogenesis |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
It is generally thought that dendritic cells are playing a pivotal role in HIV-1 transmission as they serve as the first potential targets for virus infection. The central objective of our work is to illuminate the intricate relationships between HIV-1 and dendritic cells. An improved understanding of the elaborate relationships between HIV-1 and dendritic cells is needed because it can result in the development of more appropriate and efficient preventive/therapeutic measures directed at a better control of HIV-1.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"study the control of cell proliferation and survival through protein kinase CK2"
Novelty Statement
"building on success of Gleevec to understand how CK2 allows cancer cells to acquire enhanced survival"
Methodology Innovation
computational and experimental approaches to study CK2 function