Project 170247
Control of sensory neuron development
Control of sensory neuron development
Project Information
| Study Type: | Other Basic_Science |
| Therapeutic Area: | Oncology |
| Research Theme: | Biomedical |
| Disease Area: | cancer cell nuclear organization |
Institution & Funding
| Principal Investigator(s): | Chen, Hsiao-Huei |
| Institution: | Ottawa Hospital Research Institute |
| CIHR Institute: | Neurosciences, Mental Health and Addiction |
| Program: | |
| Peer Review Committee: | New Investigators C |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
Sensory neurons are frequently lost in patients with cancer, diabetes or HIV infection. Optimally, cell based therapies to selectively replace the missing sensory neurons will require knowledge of the molecular pathways controlling sensory neuron development and function. This knowledge may also be useful to treat other sensory neuropathies affecting hearing and vision. This proposal is directed at elucidating the signaling and transcription pathways that control development and function of sensory neurons that detect muscle stretch in the "knee-jerk" reflex. We have discovered a protein that is essential for these neurons to develop and survive. Using mouse models that lack this protein, we will dissect how this protein works to control sensory neuron development.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"study the three-dimensional nuclear remodeling of telomeres in cancer"
Novelty Statement
"shown that structural order of the nucleus is changed when cells become tumor cells"
Methodology Innovation
three-dimensional imaging of nuclear telomere organization