Project 170396
The Role of the Inflammasome in Renal Injury
The Role of the Inflammasome in Renal Injury
Project Information
| Study Type: | Trial Randomized_Controlled_Trial |
| Therapeutic Area: | Psychiatry |
| Research Theme: | Biomedical |
| Disease Area: | major depressive disorder |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Muruve, Daniel A |
| Institution: | University of Calgary |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Experimental Medicine |
| Competition Year: | 2008 |
| Term: | 4 yrs 0 mth |
Abstract Summary
Kidney diseases are common in the general population. Many types of kidney disease are caused by toxins, poor circulation, diabetes and other insults. Invariably, these types of kidney injury result in either acute or chronic kidney failure which has a significant impact on patient health. When kidneys become injured, a significant component of inflammation is involved. It is known that inflammation that occurs during injury contributes to kidney failure resulting in a worse outcome. We have recently identified a new pathway of inflammation in the cell. We believe that this inflammatory pathway (called the inflammasome)is activated by the types of injury stated above such as poor circulation or toxins. The activation of the inflammasome contributes to the severity of the kidney injury and the ultimate outcome that is kidney failure. Research in this area may identify new pathways or understanding of kidney failure that can be targeted with drugs, that ultimately will help patients with kidney failure.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"evaluate the effectiveness of light and fluoxetine in nonseasonal major depression"
Novelty Statement
"investigating effects of light and ion therapy alone and in combination with antidepressant medication for nonseasonal depression"
Methodology Innovation
combination of light therapy with antidepressant medication