Project 170403
Regulation of the gene transfer agent (GTA) of Rhodobacter capsulatus
Regulation of the gene transfer agent (GTA) of Rhodobacter capsulatus
Project Information
| Study Type: | Other Basic_Science |
| Therapeutic Area: | Immunology |
| Research Theme: | Biomedical |
| Disease Area: | inflammatory and allergic diseases |
Institution & Funding
| Principal Investigator(s): | Beatty, John Thomas |
| Institution: | University of British Columbia |
| CIHR Institute: | Genetics |
| Program: | |
| Peer Review Committee: | Biochemistry & Molecular Biology - B |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
This work is to study how a bacterial cell controls the production of a virus-like particle (the gene transfer agent, or GTA) that has the sole function of transfering genes from a donor to a recipient cell. Our preliminary work indicates aspects of several changes in environmental conditions, such as the presence or absence of specific chemicals, that affect gene transfer. We wish to determine exactly how such chemicals, or 'signals', are sensed by cells and the biochemical pathways leading from signal sensation to the turn on/off of GTA genes.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"study the regulation of PAF receptor function and its role in inflammatory diseases"
Novelty Statement
"studying structure and function of PAF receptor and its role in transmitting inflammatory signals"
Methodology Innovation
study of PAF receptor structure and signaling mechanisms