Project 170534

Brain mechanisms underlying the typical and atypical development of the mathematical brain

170534

Brain mechanisms underlying the typical and atypical development of the mathematical brain

$667,110
Project Information
Study Type: Observational Cohort_Study
Therapeutic Area: Neurology
Research Theme: Not applicable / Specified
Disease Area: developmental dyscalculia, dyslexia
Data Type: Canadian
Institution & Funding
Principal Investigator(s): Ansari, Daniel
Institution: University of Western Ontario
CIHR Institute: Neurosciences, Mental Health and Addiction
Program: Operating Grant
Peer Review Committee: Behavioural Sciences - C: Behavioural Studies, Neuroscience and Cognition
Competition Year: 2008
Term: 5 yrs 0 mth
Abstract Summary

Most of us deal with numbers efficiently, oftentimes without being aware of it. A good example is reading a newspaper article. In the process of doing so, you will encounter several pieces of numerical information, such as dates, the number of people involved in a given incident, a statistic to illustrate a particular point etc. While the majority of us will process and integrate this numerical information seamlessly, there exist a substantial percentage of individuals whose intelligence is in the normal range, but who struggle with even the most basic numerical and mathematical information and problems. These individuals are said to have Developmental Dyscalculia. This specific difficulty with numbers and math presents a significant impairment to educational, social and professional development. In stark contrast to the wide body of work on the causes and symptoms of Developmental Dyslexia (specific difficulty with reading), there currently exists only a few research studies which have investigated the behavioural and brain-level characteristics of Developmental Dyscalculia. The aim of my program of research is to provide insights into the neural and behavioural roots of this disorder, in an effort to inform the design, implementation and evaluation of research-based intervention tools. More specifically, through a series of three research projects, my research lab will use brain imaging techniques to investigate a.) how individual differences in mathematical competence among typically developing children relate to brain activation and structure b.) how the brain activation and structure of children with Developmental Dyscalculia differ from children with normal mathematical skills, and c.) to understand the relationship between developmental difficulties in reading and mathematics, that is, how Dyscalculia and Dyslexia differ in terms of brain structure and function and how these groups differ from children who have both Developmental Dyscalculia and Dyslexia

Research Characteristics

This project includes the following research characteristics:

Comorbidity Focus
Cohort Establishment
Knowledge Translation Focus
Biomarker Endpoints
Composite Endpoint
Vulnerable Populations
Study Justification

"investigate how individual differences in mathematical competence among typically developing children relate to brain activation and structure"

Novelty Statement

"provide insights into the neural and behavioural roots of this disorder, in an effort to inform the design, implementation and evaluation of research-based intervention tools"

Methodology Innovation

using brain imaging to investigate relationship between mathematical competence and brain structure/function in developmental disorders

Keywords
Developmental Cognitive Neuroscience Developmental Dyscalculia Functional Magnetic Resonance Imaging Individual Differences Intraparietal Sulcus Numerical Cognition