Project 170582
The OSCILLation for ARDS Treated Early (OSCILLATE) Trial
The OSCILLation for ARDS Treated Early (OSCILLATE) Trial
Project Information
| Study Type: | Trial Randomized_Controlled_Trial |
| Therapeutic Area: | Critical_Care |
| Research Theme: | Clinical |
| Disease Area: | acute respiratory distress syndrome |
| Data Type: | Global |
Institution & Funding
| Principal Investigator(s): | Meade, Maureen O; Ferguson, Niall D |
| Co-Investigator(s): | Adhikari, Neill K; Arabi, Yaseen; Cook, Deborah J; Dorscheid, Delbert R; Freitag, Andreas P; Friedrich, Jan; Gottfried, Stewart B; Granton, John T; Guyatt, Gordon H; Jacka, Michael J; Keenan, Sean P; Lessard, Martin; Lesur, Olivier J; Mehta, Sangeeta; Patel, Rakesh V; Ronco, Juan J; Slutsky, Arthur S; Stewart, Thomas E; Walter, Stephen D |
| Institution: | McMaster University |
| CIHR Institute: | Circulatory and Respiratory Health |
| Program: | |
| Peer Review Committee: | Randomized Controlled Trials - A (RSA) |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
Acute respiratory distress syndrome (ARDS) is a common and catastrophic complication of critical illness related to burns, motor vehicle accidents, or overwhelming infection. ARDS kills 40-70% of affected patients. Patients with ARDS require life support in the form of a ventilator to breathe for them while their lungs heal. Ironically, ventilators can cause further damage to the lungs. We propose a study comparing 2 methods to protect the lungs from further damage. One method uses standard mechanical ventilators and the other uses a new type of ventilator, called a high frequency oscillator. Building on our experience with a preliminary study that showed that this is feasible, we propose to test whether this high frequency oscillation will reduce the relative risk of dying from ARDS. A total of 1200 patients will be included from 50 intensive care units in Canada and around the world.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"test whether high frequency oscillation will reduce the relative risk of dying from ARDS compared to standard mechanical ventilation"
Novelty Statement
"building on preliminary feasibility study to test high frequency oscillation for reducing ARDS mortality"
Methodology Innovation
comparing high frequency oscillation versus standard mechanical ventilation for ARDS in large multicenter trial