Project 170627
Role of microRNA in Major Depression and Suicide
170627
Role of microRNA in Major Depression and Suicide
$767,298
Project Information
| Study Type: | Other Biomarker_Study |
| Therapeutic Area: | Mental_Health |
| Research Theme: | Biomedical |
| Disease Area: | major depression, suicide |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Turecki, Gustavo X |
| Co-Investigator(s): | Gratton, Alain; Labbe, Aurelie; Mechawar, Naguib; Pavlidis, Paul |
| Institution: | CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Douglas Hospital |
| CIHR Institute: | Neurosciences, Mental Health and Addiction |
| Program: | |
| Peer Review Committee: | Behavioural Sciences - B: Clinical Behavioural Sciences |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
The major objective of this proposal is to identify microRNA differences in prefrontal cortex and hippocampus of depressed suicides compared to controls. MicroRNA are small, noncoding RNA molecules that regulate RNA expression.
Research Characteristics
This project includes the following research characteristics:
Novel Biostatistics
Comorbidity Focus
Biobank Use
Knowledge Translation Focus
Biomarker Endpoints
Vulnerable Populations
Study Justification
"identify microRNA differences in prefrontal cortex and hippocampus of depressed suicides compared to controls"
Novelty Statement
"investigating the role of microRNA, small noncoding RNA molecules that regulate RNA expression, in major depression and suicide"
Methodology Innovation
investigating microRNA expression differences in brain regions of suicide cases
Keywords
Major Depression
Microrna
Neurobiology
Suicide
Vulnerability