Project 170666
Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer
Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer
Project Information
| Study Type: | Other Biomarker_Study |
| Therapeutic Area: | Oncology |
| Research Theme: | Biomedical |
| Disease Area: | cancer |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Mai, Sabine |
| Institution: | University of Manitoba |
| CIHR Institute: | Cancer Research |
| Program: | |
| Peer Review Committee: | Cancer Biology & Therapeutics |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus. The nucleus contains our genetic information. The structural order of the nucleus is what differentiates a normal cell from a cancer cell. In other words, if the order of this structure is compromised, the cell is not normal anymore. We propose to identify mechanisms through which the structural organization of the nucleus can be changed. We will define the changes that are required for cells to become cancerous. This study is highly relevant for our understanding of early changes that lead to cancer. In the future, we propose to use the defined changes for the screening of patients at risk of cancer, for monitoring of their disease progression and of treatment success.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"identify mechanisms through which the structural organization of the nucleus can be changed and define the changes that are required for cells to become cancerous"
Novelty Statement
"We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus."
Methodology Innovation
using three-dimensional imaging and spectral karyotyping to study nuclear remodeling in cancer