Project 170691
The Clinical Investigation of Fracture Risk in Patients with Chronic Kidney Disease
The Clinical Investigation of Fracture Risk in Patients with Chronic Kidney Disease
Project Information
| Study Type: | Observational Cohort_Study |
| Therapeutic Area: | Nephrology |
| Research Theme: | Clinical |
| Disease Area: | chronic kidney disease, osteoporosis, fractures |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Jamal, Abida Sophina; Lok, Charmaine E |
| Co-Investigator(s): | Cheung, Angela M; Hawker, Gillian A; Jassal, Sarbijt V; Josse, Robert G; Ste-Marie, Louis-Georges; Tomlinson, George A |
| Institution: | University Health Network (Toronto) |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Broken bones (fractures) due to osteoporosis "or thinning of the bones" are common in men and women with kidney disease. For example, just over half of men and women with kidney failure needing dialysis will have a fracture. Fractures can cause sickness and even death. The number of Canadians requiring dialysis is increasing dramatically and, as such, the number of Canadians at risk for fractures is also increasing. By preventing fractures in dialysis patients we could dramatically improve quality of life, reduce death, and decrease health care costs. The first step in preventing fractures is to identify men and women with kidney disease at high fracture risk before they start dialysis. Our study will identify and follow (for 2 years)200 patients with kidney disease to determine who is at risk for developing fracture and what tests can identify those at highest risk. This study is the first step in reducing the death and disability due to fractures in patients with kidney failure.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"identify and follow (for 2 years)200 patients with kidney disease to determine who is at risk for developing fracture and what tests can identify those at highest risk"
Novelty Statement
"This study is the first step in reducing the death and disability due to fractures in patients with kidney failure."
Methodology Innovation
prospective cohort study to identify clinical determinants of fracture risk in patients with chronic kidney disease