Project 170693
SOCS3 regulation of insulin and leptin sensitivity in obesity
SOCS3 regulation of insulin and leptin sensitivity in obesity
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Endocrinology |
| Research Theme: | Biomedical |
| Disease Area: | obesity, metabolic syndrome, diabetes |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Steinberg, Gregory R |
| Institution: | McMaster University |
| CIHR Institute: | Nutrition, Metabolism and Diabetes |
| Program: | |
| Peer Review Committee: | Endocrinology |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Canada is experiencing an epidemic of obesity that is contributing to diabetes, heart disease, and premature death. This proposal investigates why being obese causes the metabolic syndrome with a specific emphasis on how muscle and fat respond to insulin. An improved understanding about how hormones regulates the body's storage and breakdown of fat and responsiveness to insulin will enable the development of new medicines for the treatment of obesity and the prevention of diabetes.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"investigates why being obese causes the metabolic syndrome with a specific emphasis on how muscle and fat respond to insulin"
Novelty Statement
"An improved understanding about how hormones regulates the body's storage and breakdown of fat and responsiveness to insulin will enable the development of new medicines for the treatment of obesity and the prevention of diabetes."
Methodology Innovation
investigating SOCS3 regulation of insulin and leptin sensitivity in obesity