Project 170781
Pathogen adaptation and AIDS-associated Cryptococcosis
Pathogen adaptation and AIDS-associated Cryptococcosis
Project Information
| Study Type: | Other Drug_Development |
| Therapeutic Area: | Infectious_Disease |
| Research Theme: | Biomedical |
| Disease Area: | cryptococcosis, AIDS |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Kronstad, James W |
| Co-Investigator(s): | De Repentigny, Louis |
| Institution: | University of British Columbia |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Microbiology & Infectious Diseases |
| Competition Year: | 2008 |
| Term: | 4 yrs 0 mth |
Abstract Summary
This project focuses on understanding the ways in which deadly fungal pathogens attack people with weakened immune systems. In particular, the project will study the fungal pathogen Cryptococcus neoformans. This pathogen is the most common cause of life-threatening brain infections in people with acquired immune deficiency syndrome (AIDS). The project will test whether an animal model of AIDS is useful for studying ways to treat infections caused by Cryptococcus neoformans. In addition, possible new targets for drug therapies will be examined.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"test whether an animal model of AIDS is useful for studying ways to treat infections caused by Cryptococcus neoformans. In addition, possible new targets for drug therapies will be examined."
Novelty Statement
"The project will test whether an animal model of AIDS is useful for studying ways to treat infections caused by Cryptococcus neoformans."
Methodology Innovation
using an animal model of AIDS to study cryptococcosis and identify new drug targets