Project 170783
Functional Characterization of Bone Sialoprotein
Functional Characterization of Bone Sialoprotein
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Orthopedics |
| Research Theme: | Biomedical |
| Disease Area: | bone repair |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Goldberg, Harvey A; Hunter, Graeme K |
| Institution: | University of Western Ontario |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage |
| Competition Year: | 2008 |
| Term: | 4 yrs 0 mth |
Abstract Summary
The organic matrices of mineralized tissues consist principally of type I collagen and a variety of non-collagenous proteins. These proteins are postulated to have critical roles in tissue development and the mineralization process. Studies conducted in our laboratories and elsewhere have shown that one of these proteins, bone sialoprotein, is a multifunctional protein that can interact with the mineral, cells and collagen. Bone sialoprotein can initiate mineral formation, promote osteoblast differentiation and thus new bone formation, in addition to activating osteoclasts, cells that resorb mineralized tissues. Using a wide spectrum of physical, chemical, biochemical and molecular techniques this study will focus on bone sialoprotein-collagen-mineral interactions. These studies will provide important information on the fundamental mechanism of mineralization in bone, and may lead to the development of novel therapeutic agents for the promotion of bone repair.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"this study will focus on bone sialoprotein-collagen-mineral interactions using a wide spectrum of physical, chemical, biochemical and molecular techniques"
Novelty Statement
"These studies will provide important information on the fundamental mechanism of mineralization in bone, and may lead to the development of novel therapeutic agents for the promotion of bone repair."
Methodology Innovation
using a wide spectrum of physical, chemical, biochemical and molecular techniques to study bone sialoprotein interactions