Project 170793
Macrophage Activation by Drugs Leading to Autoimmunity
Macrophage Activation by Drugs Leading to Autoimmunity
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Pharmacology |
| Research Theme: | Biomedical |
| Disease Area: | adverse drug reactions, autoimmunity |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Uetrecht, Jack P |
| Institution: | University of Toronto |
| CIHR Institute: | Population and Public Health |
| Program: | |
| Peer Review Committee: | Pharmaceutical Sciences |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
Drugs can cause serious side-effects. Some of these side-effects are mediated by the immune system (a type of allergic reaction) and are very unpredictable. We are trying to understand the basic of these side-effects so that drugs can be designed so that they are less likely to cause such adverse reactions and so that we can better predict who is likely to have such adverse reactions.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"trying to understand the basic of these side-effects so that drugs can be designed so that they are less likely to cause such adverse reactions and so that we can better predict who is likely to have such adverse reactions"
Novelty Statement
"We are trying to understand the basic of these side-effects so that drugs can be designed so that they are less likely to cause such adverse reactions and so that we can better predict who is likely to have such adverse reactions."
Methodology Innovation
investigating the role of macrophage activation in drug-induced autoimmunity