Project 170813
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME): Multi-centre, double blind Randomized Controlled Trial comparing the efficacy of Diacetylmorphine vs. Hydromorphone for the treatment of long-term Injection Opiate Users who do not benefit from available therapies
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME): Multi-centre, double blind Randomized Controlled Trial comparing the efficacy of Diacetylmorphine vs. Hydromorphone for the treatment of long-term Injection Opiate Users who do not benefit from available therapies
Project Information
| Study Type: | Trial Randomized_Controlled_Trial |
| Therapeutic Area: | Addiction |
| Research Theme: | Clinical |
| Disease Area: | opioid dependence, heroin addiction |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Krausz, Reinhard M; Oviedo-Joekes, Eugenia |
| Co-Investigator(s): | Anis, Aslam H; Brissette, Suzanne; Bruneau, Julie; Marsh, David C; Nosyk, Bohdan P; Schechter, Martin T; Schütz, Christian G |
| Institution: | St. Paul's Hospital, Vancouver |
| CIHR Institute: | Neurosciences, Mental Health and Addiction |
| Program: | |
| Peer Review Committee: | Randomized Controlled Trials - B (RSB) |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Inner city populations, particularly injection drug users, are at extremely high risk of many drug related harms including HIV, hepatitis C and overdose death. While some treatments exist, they are not optimal and people with the most severe cases of heroin addiction remain outside of the health care system. To improve the treatment of addiction, my colleagues and I are conducting innovative clinical trials that are testing whether medically prescribed heroin is a safe and effective treatment that improves on currently available therapies. We are also testing if pills can be used instead of injections and whether licensed medications can be used instead of heroin. We will give special attention to women and how they respond to the treatments we are testing. The ultimate goal of this research is to benefit both people with the most severe cases of heroin addiction as well as their communities.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"testing whether medically prescribed heroin is a safe and effective treatment that improves on currently available therapies"
Novelty Statement
"The ultimate goal of this research is to benefit both people with the most severe cases of heroin addiction as well as their communities."
Methodology Innovation
double-blind randomized controlled trial comparing diacetylmorphine vs. hydromorphone for treatment-refractory opioid use disorder