Project 170855
Understanding virological and host determinants of HIV disease progression in a cohort of slow progressors
Understanding virological and host determinants of HIV disease progression in a cohort of slow progressors
Project Information
| Study Type: | Observational Cohort_Study |
| Therapeutic Area: | Infectious_Disease |
| Research Theme: | Clinical |
| Disease Area: | HIV infection |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Tremblay, Cécile L; Bernard, Nicole F |
| Co-Investigator(s): | Angel, Jonathan B; Baril, Jean-Guy; Cote, Pierre; de Pokomandy, Alexandra; Gill, Michael J; Harris, Marianne; Kovacs, Colin; Loutfy, Mona R; Montaner, Julio S; Rachlis, Anita R; Routy, Jean-Pierre; Trottier, Benoit; Tsoukas, Christos M |
| Institution: | Centre hospitalier de l'Université de Montréal (CHUM) |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Public, Community and Population Health - B |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
A certain number of patients, very few, infected with HIV are able to control the virus with no anti-HIV medication. This group of rare patients has been identified as «long term non-progressors» and may have special mechanisms that enables them to control the virus on their own. Learning more about such mechanisms may be very important to help designing vaccines and/or new therapies or prevention strategies for HIV. We will be recruiting HIV-1 infected subjects who are long term non-progressors and patients who have a normal disease progression, to study how various factors such as the type of virus they are infected with, their immune system, or their cells, help them to control the infection. In addition, we want to determine the long-term clinical and psychological natural history of the infection for such patients and evaluate whether superinfection may alter their disease progression.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"recruiting HIV-1 infected subjects who are long term non-progressors and patients who have a normal disease progression, to study how various factors such as the type of virus they are infected with, their immune system, or their cells, help them to control the infection"
Novelty Statement
"Learning more about such mechanisms may be very important to help designing vaccines and/or new therapies or prevention strategies for HIV."
Methodology Innovation
comparing long-term non-progressors with normal progressors to understand mechanisms of HIV control