Project 171152
Detection of Acute Kidney Injury after Abdominal Aortic Aneurysm Repair: Role of New Biomarkers
Detection of Acute Kidney Injury after Abdominal Aortic Aneurysm Repair: Role of New Biomarkers
Project Information
| Study Type: | Observational Cohort_Study |
| Therapeutic Area: | Nephrology |
| Research Theme: | Biomedical |
| Disease Area: | acute kidney injury |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Garg, Amit |
| Co-Investigator(s): | Devarajan, Prasad; Devereaux, Philip J; Edelstein, Charles L; Forbes, Thomas; Lawlor, Kirk D; Lindsay, Thomas F; Mathew, Anna; Moist, Louise M; Parikh, Chirag R; Pepe, Margaret S |
| Institution: | London Health Sciences Centre Res. Inc. (Ont.) |
| CIHR Institute: | Circulatory and Respiratory Health |
| Program: | |
| Peer Review Committee: | Cardiovascular System - B: Heart and Circulation |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
About 2% of adults will develop an aneurysm or 'ballooning' of the aorta, the main blood vessel supplying the body. These aneurysms usually form close to the vessels which supply blood to the kidneys. Unfortunately when an aneurysm is being repaired, the kidneys are frequently injured. When kidney injury is severe, a patient needs an artificial kidney machine called dialysis for life support. Unfortunately we don't have good methods to detect early kidney injury after repair, and the diagnosis only becomes obvious a few days after the injury has completely occurred. In this study we will determine whether new biomarkers can better identify kidney injury after aortic aneurysm repair. If we can detect kidney injury early on, we can then consider treatments (both old and new) to help the kidneys work well under stress.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"In this study we will determine whether new biomarkers can better identify kidney injury after aortic aneurysm repair."
Novelty Statement
"If we can detect kidney injury early on, we can then consider treatments (both old and new) to help the kidneys work well under stress."
Methodology Innovation
prospective cohort study to validate novel biomarkers (urine IL-18 and NGAL) for early detection of acute kidney injury after abdominal aortic aneurysm repair