Project 171371
Neurobiology of resilience and vulnerability to chronic stress: Involvement of endogenous opioid circuitry
Neurobiology of resilience and vulnerability to chronic stress: Involvement of endogenous opioid circuitry
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Mental_Health |
| Research Theme: | Biomedical |
| Disease Area: | depression, anxiety |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Drolet, Guy |
| Institution: | Centre hospitalier de l'Université Laval (Québec) |
| CIHR Institute: | Neurosciences, Mental Health and Addiction |
| Program: | |
| Peer Review Committee: | Behavioural Sciences - A: Neurobiological Basis of Behavioural Processes |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
These experiments will help unravel the organization of opioid neuronal systems related to the stress response, and their role in adaptation to chronic stress. The relevance of the role(s) played by enkephalin and dynorphin in adaptation to stress may be critical in the etiology and pathology of physiological or psychiatric disorders associated with repeated or prolonged stress, such as affective and anxiety disorders.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"These experiments will help unravel the organization of opioid neuronal systems related to the stress response, and their role in adaptation to chronic stress."
Novelty Statement
"The relevance of the role(s) played by enkephalin and dynorphin in adaptation to stress may be critical in the etiology and pathology of physiological or psychiatric disorders associated with repeated or prolonged stress, such as affective and anxiety disorders."
Methodology Innovation
investigating the role of endogenous opioid circuitry (enkephalin and dynorphin) in adaptation to chronic stress