Project 171414
Role of Lipids and Lipoproteins in Modifying the Biological Activity of Hydrophobic Drugs
Role of Lipids and Lipoproteins in Modifying the Biological Activity of Hydrophobic Drugs
Project Information
| Study Type: | Other Drug_Development |
| Therapeutic Area: | Pharmacology |
| Research Theme: | Biomedical |
| Disease Area: | fungal infections |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Wasan, Kishor M |
| Institution: | University of British Columbia |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Industry Partnered Collaborative Research |
| Competition Year: | 2008 |
| Term: | 4 yrs 0 mth |
Abstract Summary
The plasma lipoprotein distribution of potential drug candidates is not commonly studied. For some hydrophobic drug candidates, attainment of similar plasma free drug levels has not been associated with uniform production of pharmacological activity in different animal species. It is well known that plasma lipoprotein lipid profiles vary considerably between different animal species. In addition, human disease states can significantly influence plasma lipoprotein profiles, resulting in altered drug therapeutic outcomes. A plausible explanation for these findings may be a result of lipoprotein drug transport within the systemic circulation. Elucidation of the mechanisms that dictate the lipoprotein binding of drugs may yield valuable insight into the factors governing the pharmacological activity and potential toxicity of these compounds. Furthermore, utilizing these factors to target compounds specifically to one lipoprotein subclass over another potentially could improve the drug's efficacy and safety.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"Elucidation of the mechanisms that dictate the lipoprotein binding of drugs may yield valuable insight into the factors governing the pharmacological activity and potential toxicity of these compounds."
Novelty Statement
"Furthermore, utilizing these factors to target compounds specifically to one lipoprotein subclass over another potentially could improve the drug's efficacy and safety."
Methodology Innovation
investigating the role of lipids and lipoproteins in modifying the biological activity of hydrophobic drugs, with the goal of improving drug efficacy and safety