Project 171470
The role of Epidermal Growth Factor Receptor Family in mammary tumorigenesis and metastasis
The role of Epidermal Growth Factor Receptor Family in mammary tumorigenesis and metastasis
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Cancer |
| Research Theme: | Biomedical |
| Disease Area: | breast cancer |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Muller, William J |
| Institution: | McGill University |
| CIHR Institute: | Genetics |
| Program: | |
| Peer Review Committee: | Genetics |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
Elevated expression of members of a class of growth factor receptors known as the epidermal growth factor receptor (EGFR) family have been implicated as important determinants the induction of breast cancer. The major focus of this renewal application is assess the relative contribution of the different EGFR family members to various stages of breast cancer progression. To accomplish this we taken advantage of number of mouse models of human breast cancer and have used both biochemical and genetic approaches to functionally attenuate different members EGFR in the mammary epithelium. The results of these studies will provide important therapeutic targets to target breast cancer progression.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"The major focus of this renewal application is assess the relative contribution of the different EGFR family members to various stages of breast cancer progression."
Novelty Statement
"The results of these studies will provide important therapeutic targets to target breast cancer progression."
Methodology Innovation
using mouse models of human breast cancer to assess the contribution of different EGFR family members to breast cancer progression