Project 171491
Characterization and efficacy of bisphosphonate eluting orthopaedic implants
Characterization and efficacy of bisphosphonate eluting orthopaedic implants
Project Information
| Study Type: | Other Drug_Development |
| Therapeutic Area: | Musculoskeletal |
| Research Theme: | Biomedical |
| Disease Area: | joint replacement |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Bobyn, John D; Tanzer, Michael |
| Co-Investigator(s): | Barralet, Jake E |
| Institution: | Research Institute of the McGill University Health Centre |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Biomedical Engineering |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Many joint replacement devices are attached directly to bone by encouraging bone formation in and around the implant surface. The use of drugs such as bisphosphponates that enhance local bone formation would improve the efficacy and longevity of implant fixation. Attaching bisphosphonate compounds directly to an implant for progressive release to surrounding bone is a simple and effective means to achieve this goal.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"The use of drugs such as bisphosphponates that enhance local bone formation would improve the efficacy and longevity of implant fixation. Attaching bisphosphonate compounds directly to an implant for progressive release to surrounding bone is a simple and effective means to achieve this goal."
Novelty Statement
"Many joint replacement devices are attached directly to bone by encouraging bone formation in and around the implant surface."
Methodology Innovation
developing bisphosphonate-eluting orthopaedic implants for enhanced bone formation and implant fixation