Project 171625
Shaping the euchromatic and heterochromatic landscapes by p400 complex-mediated incorporation of H2A.Z within chromatin
Shaping the euchromatic and heterochromatic landscapes by p400 complex-mediated incorporation of H2A.Z within chromatin
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Cancer |
| Research Theme: | Biomedical |
| Disease Area: | cancer |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Gaudreau, Luc R |
| Co-Investigator(s): | Robert, François |
| Institution: | Université de Sherbrooke |
| CIHR Institute: | Genetics |
| Program: | |
| Peer Review Committee: | Biochemistry & Molecular Biology - B |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
How genes are regulated is a major step in defining differences amongst all living organisms, and improper regulation of genes can also lead to cancer development. There is overwhelming evidence suggesting that regulators of gene expression are involved in cancer development when mutations alter their normal function. Our research group is interested in the study of components that regulate the expression of genes but more so in a global fashion such as to maintain the integrity of the human genome. It is expected that our research will generate fundamental knowledge as to the implication of chromatin components in cancer progression.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"Our research group is interested in the study of components that regulate the expression of genes but more so in a global fashion such as to maintain the integrity of the human genome."
Novelty Statement
"It is expected that our research will generate fundamental knowledge as to the implication of chromatin components in cancer progression."
Methodology Innovation
investigating the role of the p400 complex in shaping euchromatic and heterochromatic landscapes through H2A.Z incorporation