Project 171662
Primary prevention of asthma: The impact of the multifaceted intervention program in early life on outcomes in teenagers
Primary prevention of asthma: The impact of the multifaceted intervention program in early life on outcomes in teenagers
Project Information
| Study Type: | Trial Randomized_Controlled_Trial |
| Therapeutic Area: | Respiratory |
| Research Theme: | Biomedical |
| Disease Area: | asthma |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Becker, Allan B; Chan-Yeung, Moira |
| Co-Investigator(s): | Chan, Edmond S; Chen, Edith; Ferguson, Alexander C; Hayglass, Kent T; Kozyrskyj, Anita L; Miller, Gregory E; Ward, Helen |
| Institution: | University of Manitoba |
| CIHR Institute: | Circulatory and Respiratory Health |
| Program: | |
| Peer Review Committee: | Respiratory System |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
We undertook a multifaceted intervention program during the last trimester of pregnancy and the first twelve months of life in children at high risk for the development of asthma, based on a strong family history. This intervention during a "window of opportunity" in early life had a significant impact in follow-up at 1, 2 and 7 years of age for its ability to decrease asthma. We ask whether this early life intervention will continue to have impact in children in their teenage years. We will assess the progress of asthma in this group of children, measure the degree of airway responsiveness and presence of allergy and evaluate the impact of gender differences over time. We believe that early life and current psychosocial stressors will have impact on the clinical, physiologic, and immune status of these teenagers.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"We ask whether this early life intervention will continue to have impact in children in their teenage years."
Novelty Statement
"We believe that early life and current psychosocial stressors will have impact on the clinical, physiologic, and immune status of these teenagers."
Methodology Innovation
long-term follow-up of a primary prevention trial for asthma, assessing the impact of an early life intervention on teenage outcomes