Project 171692
A novel pathway of PI(3,4)P2/PI(3,4,5)P3 production initiated by a bacterial phosphatase
A novel pathway of PI(3,4)P2/PI(3,4,5)P3 production initiated by a bacterial phosphatase
Project Information
| Study Type: | Other Mechanistic_Study |
| Therapeutic Area: | Infectious_Disease |
| Research Theme: | Biomedical |
| Disease Area: | Salmonella infection, cancer, bipolar disorder, Type 2 diabetes |
| Data Type: | Canadian |
Institution & Funding
| Principal Investigator(s): | Brumell, John H |
| Institution: | Hospital for Sick Children (Toronto) |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Microbiology & Infectious Diseases |
| Competition Year: | 2008 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Some bacteria have the remarkable ability to invade our cells and replicate within them during infection. Such bacteria use special toxins to alter the control systems of our cells. These toxins cause drastic changes to the membranes of our cells, forcing them to internalize the bacteria and in the process providing them with a specialized compartment that allows the microorganisms to replicate inside our cells. Salmonella, best known for its ability to cause 'food poisoning', is one type of bacteria that can parasitize our cells in this manner. In this study we will examine how a Salmonella toxin, called SopB, can alter cellular membranes to invade our cells. The membrane alterations caused by SopB are related to those that occur during other human diseases, including cancer, bipolar disorder and Type 2 diabetes. Therefore these studies will provide a new fundamental understanding not only of bacterial infection but also of other human diseases, possibly allowing the development of new treatments.
Research Characteristics
This project includes the following research characteristics:
Study Justification
"In this study we will examine how a Salmonella toxin, called SopB, can alter cellular membranes to invade our cells."
Novelty Statement
"The membrane alterations caused by SopB are related to those that occur during other human diseases, including cancer, bipolar disorder and Type 2 diabetes. Therefore these studies will provide a new fundamental understanding not only of bacterial infection but also of other human diseases, possibly allowing the development of new treatments."
Methodology Innovation
investigating the molecular mechanism of the Salmonella toxin SopB in altering host cell membranes