Project 172080
Mechanisms of the anti-cancer actions of arsenic.
Mechanisms of the anti-cancer actions of arsenic.
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Miller, Wilson H |
| Co-Investigator(s): | Mann, Koren K |
| Institution: | CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General |
| CIHR Institute: | Cancer Research |
| Program: | |
| Peer Review Committee: | Cancer Progression & Therapeutics |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
Although considerable progress has been made in understanding the biology of cancer, effective novel therapeutics are still urgently needed in human malignancies. We have studied the mechanism of action of arsenic and found that it turns on specific cellular signaling pathways and can induce cancer cells to undergo a form of programmed cell death. Through understanding of these signaling pathways, we can develop combinations with other drugs currently used or under development. This application proposes to further study the mechanisms by which arsenic kills tumor cells and use arsenic to enhance the tumor killing with other drugs. Our goal is to increase anti-tumor activity without significantly increasing toxicity to the normal cells.
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