Project 172135
MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family
MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Thibodeau, Jacques |
| Institution: | Université de Montréal |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Immunology & Transplantation |
| Competition Year: | 2008 |
| Term: | 5 yrs 0 mth |
Abstract Summary
The immune system protects humans against pathogens and inflammation (redness, heat, swelling...) is part of the healing process. However, the body must put an end to these reactions in order to prevent complications and even auto-immune diseases. We have identified a molecule (MARCH1) that acts as a brake in the presence of anti-inflammatory messages such as the cytokine IL-10. MARCH1 acts by modifying the structure of other proteins through the addition of a ubiquitin tag. Our goal is to understand the regulation of MARCH1 in immune cells, identify its molecular targets and to characterize its structure and function. These results will help understanding inflammation, autoimmunity and possibly control organ transplantation.
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