Project 176102
Role of Machanosensitive Pathways in Ligament Remodelling
Role of Machanosensitive Pathways in Ligament Remodelling
Project Information
| Study Type: | Unclear |
| Research Theme: | Clinical |
Institution & Funding
| Principal Investigator(s): | Bray, Robert C |
| Co-Investigator(s): | Salo, Paul T |
| Institution: | University of Calgary |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage |
| Competition Year: | 2008 |
| Term: | 1 yr 0 mth |
Abstract Summary
Injury to the anterior cruciate ligament (ACL) causes instability of the knee, resulting in other knee structures being subjected to abnormal forces. These supporting joint connective tissues such as the medial collateral ligament respond to joint onstability by forming a scar, becoming inflamed, and increasing their blood supply. This results in pain and swelling of the knee and eventually leads to ostoearthritis. The aim of this work is to determine how altered mechanics of the knee joint after tearing of the ACL are responsible for the initiation and propagation of ligament remodelling and inflammation in the ACL deficient knee.
No special research characteristics identified
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