Project 176107
Regulation and Function of Periostin in Wound Healing
Regulation and Function of Periostin in Wound Healing
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Hamilton, Douglas W |
| Institution: | University of Western Ontario |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage |
| Competition Year: | 2008 |
| Term: | 1 yr 0 mth |
Abstract Summary
During healing of skin, cells form a scaffold within the wound known as the provisional matrix. The matrix allows cells to move into the wound and repair the damaged tissue. The matrix is composed of many different proteins, some of which are only expressed in injuries. These proteins are known as matricellular proteins and we will study how one member of this family, periostin, helps skin wounds close. Periostin appears in the wound at 3 days and we will use in vitro and in vivo experiments to assess the molecular regulation of periostin, and what functions it plays in the repair process. This proposal could provide new targets to help speed wound repair in skin.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.