Project 411096

Over the last 3 decades, it has become increasingly apparent that health research needs to account for gender and sex in order to apply research findings appropriately, develop technologies and policies, and make well-informed clinical decisions for people of all genders. Similarly, research has shown clearly that many types of biological processes occur differently at different points in the lifespan, and in order to do research that promotes healthy development and aging, our research must account for these trajectories. Addressing these considerations in laboratory-based experimental research has particular complexities and opportunities, and requires attention to the realities and context of research done using cells, experimental animals, and tissues. In this application, our team proposes to develop a suite of resources for biomedical researchers to use that will enhance their ability to incorporate gender, sex, and aging considerations into experimental laboratory-based research. We will build a comprehensive tissue bank and database to allow researchers to benchmark and validate their findings with respect to important signifiers of gender, sex, and aging, and use that information to identify 'molecular signatures' that can provide insight into function, and aim to validate these against large human databases. We will develop conceptual models of gender, sex, and aging that are specifically tailored for biomedical researchers, along with statistical and data presentation approaches. In terms of Education & Training, we will develop courses for university students across the country to build capacity in these areas, and pilot a consultant position to assist established researchers in applying these insights to their specific research contexts. Our Knowledge Translation activities will aim to put tailored resources into the hands of biomedical researchers, and evaluate the impact of these efforts as we proceed.