Project 450734

Background: Sleeve gastrectomy bariatric surgery for the treatment of obesity is increasingly popular in Canada, and this trend is unlikely to abate. Older bariatric procedures that reduce absorption of nutrients have been associated with bone fragility and muscle wasting, the magnitude of which vary in men, premenopausal and postmenopausal women. It is uncertain whether this is the case for sleeve gastrectomy, especially in the longer term. Objectives: This project aims to evaluate whether sleeve gastrectomy affects bone and muscle quantity, quality and solidity in men, premenopausal and postmenopausal women using state-of-the-art methods. Research project: Men, premenopausal and postmenopausal women undergoing sleeve gastrectomy and controls not undergoing surgery will be recruited at 3 major bariatric surgery centres in the province of Quebec. Various tests to evaluate bone and muscle health will be done before and at one year and 3 years following surgery. Relevance: It is important to know the longer-term effects of the increasingly performed sleeve gastrectomy on bone and muscle health in men, premenopausal and postmenopausal women. This is necessary to know if we should start screening for bone and muscle health after sleeve gastrectomy, for how long and which groups are at higher risk of adverse outcomes and should be specifically targeted. Moreover, this study will inform on which components of bone/muscle need to be addressed in each group, and on the best timing for intervention.