Project 454567
Role of the TGFb-Activated Kinase 1 in mesenchymal progenitors. A key modulator of the inflammatory environment in chronic diseases.
Role of the TGFb-Activated Kinase 1 in mesenchymal progenitors. A key modulator of the inflammatory environment in chronic diseases.
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Theret, Marine |
| Supervisor(s): | Rossi, Fabio M |
| Institution: | University of British Columbia |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Fellowships - Post-PhD |
| Competition Year: | 2021 |
| Term: | 1 yr 0 mth |
Abstract Summary
Beside its function as a biological barrier for infection, the immune system participates in multiple cellular process involved in tissue homeostasis during development, post-natal growth, regeneration/repair, and aging. To do this, immune cells strongly interact with tissue-resident cells, such as mesenchymal progenitors (MPs). This is a two-way relationship, as MPs are also required to maintain organ function and tissue integrity, by strongly influencing immune cells inflammatory function. A stable type 2 inflammatory environment is an important, yet underestimated, parameter required for successful tissue maintenance. While the immune functions of MPs are actively studied, the signaling pathways involved in their regulation, which are likely to provide potential therapeutic targets, are so far poorly understood.
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