Project 454691
Uncovering the Role of anti-microbial Autophagy and AMPK signaling in Crohn's Disease
Uncovering the Role of anti-microbial Autophagy and AMPK signaling in Crohn's Disease
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Gatica Mizala, Damian |
| Supervisor(s): | Russell, Ryan |
| Institution: | University of Ottawa |
| CIHR Institute: | Nutrition, Metabolism and Diabetes |
| Program: | |
| Peer Review Committee: | Fellowships - Post-PhD |
| Competition Year: | 2021 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Autophagy is a cellular degradation process in which different resident and foreign unwanted intracellular components are digested. Autophagy is activated by different cellular stresses such as starvation, infection, protein aggregation, and organelle damage. Dysregulation of the autophagy pathway has been implicated in several diseases including Crohn's Disease, cancer, neurodegeneration and cardiomyopathy. However, there is still a lot we don't know about how the autophagy pathway is regulated which has hindered our ability to generate new drugs that can target this promising pathway. The goal of this project is to study and understand how different autophagy-related genes coordinate the anti-microbial response, as well as to discover new targeted treatment strategies to rescue autophagy defects in Crohn's Disease patients.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.