Project 454697
Protective role of plasminogen deficiency in non-alcoholic fatty liver disease and glucose dysmetabolism
Protective role of plasminogen deficiency in non-alcoholic fatty liver disease and glucose dysmetabolism
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Hur, Woo suk |
| Supervisor(s): | Flick, Matthew J |
| Institution: | University of North Carolina (Chapel Hill) |
| CIHR Institute: | Nutrition, Metabolism and Diabetes |
| Program: | |
| Peer Review Committee: | Fellowships - Post-PhD |
| Competition Year: | 2021 |
| Term: | 2 yrs 0 mth |
Abstract Summary
Non-alcoholic fatty liver disease is a growing health problem that affects over 8 million Canadians. Patients with fatty liver disease are more likely to experience liver failure, stroke and heart disease. Currently, there is no approved therapy for fatty liver disease. Identifying the key factors that lead to fatty liver disease will help generate new treatment options. We used an animal model and found that plasminogen (a protein important in clearing blood clots) promotes fatty liver disease in obese mice. In this proposal, I will study how plasminogen influences the development of fatty liver disease. My proposal will identify new treatment strategies for fatty liver disease to help prevent diabetes, stroke, and heart disease and reduce the health burden of fatty liver disease among Canadians.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.