Project 456392
Regulation of the inflammatory response by NOX2-derived reactive oxygen species
Regulation of the inflammatory response by NOX2-derived reactive oxygen species
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Touzot, Fabien |
| Co-Investigator(s): | Caron, Etienne; Falcone, Emilia L |
| Institution: | Centre hospitalier universitaire Sainte-Justine (Montréal, Québec) |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Immunology & Transplantation |
| Competition Year: | 2021 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Reactive oxygen species (ROS) are oxygen derivatives produced by the cells in response to various stimuli. They are involved in the regulation of numerous cellular processes. Prolonged ROS production is a well-recognized contributor to chronic inflammation underlying many human diseases. In contrast to this concept, our group has recently shown that a defective production of ROS in a primary human immunodeficiency called Chronic Granulomatous Disease is responsible for increased inflammation. Our research proposal aims to elucidate this biological paradox by deciphering the pathophysiological mechanisms responsible for inflammation in the absence of ROS production. We anticipate that this approach can help developing of alternative therapeutic options for managing patients with chronic inflammation.
No special research characteristics identified
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