Project 456410
The implication of PlGF in cutaneous fibrosis
456410
The implication of PlGF in cutaneous fibrosis
$100,000
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Moulin, VĂ©ronique |
| Institution: | CHU de Québec |
| CIHR Institute: | Musculoskeletal Health and Arthritis |
| Program: | |
| Peer Review Committee: | Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage |
| Competition Year: | 2021 |
| Term: | 1 yr 0 mth |
Abstract Summary
There are many diseases that result in an increase in the amount of extracellular matrix, making the skin hard and inelastic. Among these diseases, scleroderma and hypertrophic scars are two disabling conditions that currently receive little effective treatment. We have determined that a molecule called PlGF stimulates the production of the extracellular matrix and is greatly increased in patients with this disease. Our study aims to understand the link between PlGF and fibrosis in order to be able to better control the evolution of these diseases.
No special research characteristics identified
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Keywords
Collagen
Cytokine
Fibrosis
Hypertrophic Scar
Plgf
Scleroderma
Skin