Project 458127
Pairing pooled CRISPR/Cas9 screens with high-resolution multiplexed approaches to study cell competition and pre-malignancy in breast and skin epithelium
Pairing pooled CRISPR/Cas9 screens with high-resolution multiplexed approaches to study cell competition and pre-malignancy in breast and skin epithelium
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Teng, Katie |
| Supervisor(s): | Schramek, Daniel; Jackson, Hartland W |
| Institution: | Sinai Health System (Toronto) |
| CIHR Institute: | Cancer Research |
| Program: | |
| Peer Review Committee: | Doctoral Research Awards - A |
| Competition Year: | 2021 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Many healthy adult tissues, such as the breast and skin, contain cells that carry mutations that accumulate with age and are linked to cancer development. Although many cells are known to be mutated in normal tissues, mechanisms such as cell competition are in place to eliminate abnormal cells and maintain tissue health. However, certain alterations may give a cell a growth and/or proliferative advantage over healthy cells. These cell populations can then further evolve into precancerous lesions and eventually malignant tumours. It is, therefore, necessary to establish innovative systems to study the burden of mutations in phenotypically normal breast and skin tissues. From our study, we hope to unveil the earliest essential steps in breast and skin cancer development and unravel the molecular pathways implicated which will help guide the development of preventative, diagnostic and treatment strategies.
No special research characteristics identified
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