Project 458230
The role of peptidylarginine deiminase 4 and neutrophil extracellular traps in vascular damage in hypertension and diabetes
The role of peptidylarginine deiminase 4 and neutrophil extracellular traps in vascular damage in hypertension and diabetes
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Landry, Chloé |
| Supervisor(s): | Burger, Dylan E |
| Institution: | University of Ottawa |
| CIHR Institute: | Circulatory and Respiratory Health |
| Program: | |
| Peer Review Committee: | Doctoral Research Awards - A |
| Competition Year: | 2021 |
| Term: | 3 yrs 0 mth |
Abstract Summary
The immune system is essential to protect the body from disease-causing bacteria or viruses. One way that the immune system protects the body is by releasing "extracellular traps". These traps are made from webs of DNA that capture bacteria. However, these webs of DNA can also cause damage to the body themselves. In particular, "extracellular traps" can cause heart and, autoimmune diseases. This project will study the role of the immune system in high blood pressure (hypertension) and diabetes. We will study the ways by which hypertension and diabetes can cause immune system activation and damage to blood vessels. We will also determine if extracellular traps can predict organ damage in hypertension and diabetes. The proposed study will thus shed light on the role of the immune system in hypertension and diabetes and could identify new drug targets for the prevention of organ damage in hypertension and diabetes.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.