Project 458466
Genetic and chemical perturbations of Staphylococcus aureus adhesion to the host epithelium
Genetic and chemical perturbations of Staphylococcus aureus adhesion to the host epithelium
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Leonard, Allison |
| Supervisor(s): | Cox, Georgina |
| Institution: | University of Guelph |
| CIHR Institute: | Infection and Immunity |
| Program: | |
| Peer Review Committee: | Doctoral Research Awards - A |
| Competition Year: | 2021 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Antibiotic resistance is an ever-growing global crisis. Driving antibiotic resistance is the fact that traditional antibiotics work to kill bacteria that are causing infections. This puts pressure on the bacteria to adapt so they can survive, thus developing resistance. We are in a dire need of new ways to treat bacterial infections. One option that has gained traction is to target a bacteria's ability to cause infection by preventing bacteria from sticking to human cells (also known as adhesion) rather than inhibiting growth. Inhibiting adhesion would enable the bacteria to be flushed out by the host immune system before it can establish an infection. The purpose of my research is to find and characterize compounds that target adhesion in the antibiotic-resistant bacteria Staphylococcus aureus. The discovery of such a compound would provide a new and effective approach for preventing and/or treating S. aureus infections.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.