Project 460161
Nutrient sensing and metformin action in the gut
Nutrient sensing and metformin action in the gut
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Lam, Tony K |
| Institution: | University Health Network (Toronto) |
| CIHR Institute: | Nutrition, Metabolism and Diabetes |
| Program: | |
| Peer Review Committee: | Diabetes, Obesity, Lipid & Lipoprotein Disorders |
| Competition Year: | 2022 |
| Term: | 5 yrs 0 mth |
Abstract Summary
The hallmark feature of obesity-associated type 2 diabetes is elevated blood glucose levels and body weight. The gastrointestinal tract regulates glucose levels, food intake and body weight in rodents and humans, but the mechanism remains largely elusive. In this 5-yr project application, we propose to study molecular mechanism in the small intestine that mediate the sensing of protein and metformin action to regulate glucose homeostasis, feeding and body weight in male and female rats. We aim to identify therapeutic molecules within the small intestine that will lower glucose levels and body weight in diabetes and obesity.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.