Project 460556
Role of post-translational modifications on TDP-43's aggregation propensity
Role of post-translational modifications on TDP-43's aggregation propensity
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Camilus, Nayomi S |
| Supervisor(s): | Martic, Sanela |
| Institution: | Trent University (Peterborough, Ontario) |
| CIHR Institute: | Aging |
| Program: | |
| Peer Review Committee: | Summer Program in Aging |
| Competition Year: | 2022 |
| Term: | 1 yr 0 mth |
Abstract Summary
Human diseases like Amyotrophic lateral sclerosis (ALS), affecting an estimated 3,000 Canadians, are detrimental and currently do not have a cure. To understand how we can find therapies, we first need to understand the biology of how the disease works. This can be done by studying the key protein that is responsible for these detrimental effects in individuals. The proposed research aims to use the key protein involved, modify it under control conditions and finally, test how those modifications affect the protein's structure and behaviour. By understanding how modifying the key protein involved in ALS affects its structure and function, it will allow for the development of therapeutics that target them.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.