Project 461063

A hallmark feature of eukaryotic cells is the separation of nuclear and cytoplasmic compartments by the nuclear membrane. The bidirectional transfer of macromolecules between these compartments occurs through a large proteins complex termed the nuclear pore complex (NPC). This transport of macromolecules through the NPC is highly regulated and dynamic. Consistent with the central role of nucleocytoplasmic transport in the regulation of many crucial processes required for cells to function, defects in this process, either by mutations or misregulation of factors involved in this process, is associated with many disease phenotypes, including cancer, neurodegenerative diseases such as ALS, muscular dystrophy and premature aging syndrome. Moreover, interactions with the transport machinery are central for many viruses to replicate. A better understanding of this complex process is therefore essential to better understand various diseases, as well as to allow finding possible treatments of various diseases, and has been an active research field for many years. The Nuclear Transport Meeting 2022, which takes place for the 14th time on September 18-23, 2022, at Estérel Resort, Quebec, Canada, brings together the leaders of the nuclear transport field to share their research and to discuss progress and challenges in the field. Delayed for a year due to the COVID pandemic, this meeting will be an important opportunity for the research community to reconnect, as well as allow the Canadian nuclear transport community to better integrate at the international stage.