Project 461883
Cardioprotection during hypertensive heart disease is mediated through anti-viral cytokine pathways
Cardioprotection during hypertensive heart disease is mediated through anti-viral cytokine pathways
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | Epelman, Slava |
| Institution: | University Health Network (Toronto) |
| CIHR Institute: | Circulatory and Respiratory Health |
| Program: | |
| Peer Review Committee: | Cardiovascular System - B: Heart and Circulation |
| Competition Year: | 2022 |
| Term: | 5 yrs 0 mth |
Abstract Summary
High blood pressure is a common risk factor for patients to develop a weak and/or stiff heart. When the heart develops problematic changes in response to high blood pressure, heart failure can occur - a condition with a poor prognosis. We have unexpectantly discovered that an anti-viral pathway protect the heart against the development of heart failure in response to high blood pressure. This grant will define the heart cell types which provide protection when sensing the anti-viral mediators while the heart is under stress. We will also determine whether patients with heart failure have impaired anti-viral responses that could contribute to heart failure development.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.