Project 466987

Obesity is a major global health problem as it poses a significant risk for many chronic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation is a central player in the mechanisms underlying these chronic diseases. Growing scientific evidence suggests that adipose tissue is the primary origin of inflammation, thus making it a promising target for prevention and management of chronic diseases. Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients in our diet and have been suggested to have a beneficial impact on dampening adipose tissue inflammation. The limited literature on this relationship drives this study, in which we aim to investigate the role of omega-3 PUFAs in adipose tissue inflammation by performing a systematic review of current literature as well as by evaluating the long-term association between the omega-3 PUFAs and changes in adipose tissue inflammation among participants in the PROMISE cohort study.