Project 467222

Autism spectrum disorder (ASD) is a neurodevelopmental condition that has been diagnosed in approximately 1 out of 66 children between 5 to 17 years of age in Canada. Altered sensory processing is commonly observed in ASD, especially hypersensitivity to sound. Sounds that are not bothersome to neurotypical individuals may seem threatening or uncomfortable to autistic individuals. Acoustic hypersensitivity has many social and academic implications as it can impact an individual's sleep health, ability to concentrate, emotional wellbeing, and mental health. Considering the impact that acoustic hypersensitivity can have on daily life, it is important to understand the underlying neurological mechanisms, which are currently unknown. Using a genetic rat model of ASD, I will conduct electrophysiological recordings in specific brain regions to investigate the neural basis of acoustic hypersensitivity. Upon understanding the neural changes associated with altered sensory processing in ASD, future studies could investigate potential therapeutic strategies to attenuate acoustic hypersensitivity and the detrimental impact that it can have on autistic individuals.