Project 467253

The World Health Organization and International Labour Organization (WHO/ILO) have attributed 1.9 million deaths globally to occupational exposures in 2016. The long-term effects of many occupational exposures on lung health and prospective lung function decline remain unclear.We hypothesize that the same job/occupational exposures will have different magnitudes of effect across populations of different socioeconomic and environmental (SES) backgrounds. Due to the effect of co-exposures from other risk factors for poor lung health, lower SES groups will likely have larger disease burden for the same exposures. The objectives are: 1) to examine the job categories associated with excessive lung function decline compared to reference groups without the job exposure; 2) to examine the consistency of associations and magnitude of effect by country income levels.The Prospective Urban Rural Epidemiology (PURE) Study is an international multicenter observational study which has enrolled 225,000 adults across 27 low-, middle- and high-income countries.Using self-reported job titles we will classify the occupational variable using the International Standard Classification of Occupations (ISCO) for job categorization. Lung function decline per year in Forced Expiratory Volume in 1 second (FEV1) and Forced Vital Capacity (FVC) will be reported across job categories with exposure and nonexposure.SES factors have an important impact on the effect of exposures on lung health, and the magnitude of their modifying effect can help inform the likely risk of job exposures on lung health according to a population's SES status. Current underestimation of exposures in lower SES countries may cause greater burden of disease, where valid comparisons between populations are needed.

Airborne/Respirable Exposures Chronic Obstructive Pulmonary Disease (Copd) Global Disease Burden High- International Standard Classification Of Occupations Job Exposure Matrix Low-Income Lung Function Middle- Occupational Disease Occupational Mortality And Multimorbidity Ses-Occupational Epidemiology Interaction