Project 467520
Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
Project Information
| Study Type: | Unclear |
| Research Theme: | Biomedical |
Institution & Funding
| Principal Investigator(s): | O'Reilly, Meaghan |
| Institution: | Sunnybrook Research Institute (Toronto, Ontario) |
| CIHR Institute: | Neurosciences, Mental Health and Addiction |
| Program: | |
| Peer Review Committee: | Special Cases |
| Competition Year: | 2022 |
| Term: | 3 yrs 0 mth |
Abstract Summary
Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer's disease (AD). When combined with ultrasound contrast agents (termed 'microbubbles') that are administered to the blood stream, FUS can temporarily and reversibly permeabilize the blood vessels in the brain. The microbubbles vibrate in response to the ultrasound and enhance the delivery of drugs from the bloodstream to the tissue. However, in addition to enabling the delivery of drugs, this treatment has been observed in animal studies to improve the clearance of harmful waste, such as beta amyloid plaques, from the brain and improve cognitive performance in behavioral tests. In this study we will investigate the mechanism of enhanced clearance. Specifically we will study the effect of Piezo1, which is sensitive to mechanical stimuli, on these treatments in mice.
No special research characteristics identified
This project does not include any of the advanced research characteristics tracked in our database.