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Showing 7651-7698 of 7698 projects for "cancer"
PI: Chevrette, Mario
Numerous genetic changes occur as prostate cancer becomes more aggressive. We have shown that one such change is the loss of expression of CD9, a protein which is also lost in other human cancers. Re…
Our research indicates that over 50% of breast cancer survivors may experience arm problems after treatment. These problems can be disabling, but few researchers have examined the impact of these cha…
The tumor suppressor pRb is lost by mutations or functional inactivation in most, if not all, human cancers. The prevailing view is pRb controls cell proliferation and survival as well as differentia…
PI: Lee, Hoyun
Copying of the entire genetic material (i.e., DNA) accurately and timely is essential for maintaining genetic stability in all living organisms, and the deregulation of this process is directly relev…
PI: Frappier, Lori D
Human cell nuclei contain several structures referred to as PML bodies because PML (promyelocytic leukemia) proteins form the basis of these structures and alterations to the PML proteins result in l…
We know that screening mammograms to find breast cancer save lives, from many reliable studies. However, no reliable study has ever been done to find out if the same is true about check-up mammograms…
Role of the atypical ERK3/ERK4-MK5 signaling pathway in cell cycle progression and tumorigenesis
PI: Meloche, Sylvain
MAP kinases are a family of enzymes that play important roles in the control of cell proliferation and survival. Accumulating evidence suggests that these enzymes may be implicated in the pathogenesi…
PI: Riddick, David S
Hormones are the chemical messengers of the endocrine system that regulate the body's normal functions, and they are also critical in playing adaptive roles in response to events outside the body. So…
PI: Fenster, Aaron
With the exception of non-melanomatous skin cancer, prostate cancer is the most commonly diagnosed cancer and the third highest cause of cancer related mortality in men. It is found at autopsy in 40%…
PI: Bedell, Barry J
While significant advances have recently been made in the treatment of a variety of cancers, brain tumours called gliomas have generally remained resistant to current drugs. As such, there currently …
PI: Baldwin, Troy A
T cells are a type of white blood cell that are critical for providing protection against infections and cancer. T cells mature in an organ called the thymus. It is in the thymus where the ability of…
PI: Riggs, Wayne K; Grigliatti, Thomas A; Reid, Ronald E
The reductases are metabolic enzymes responsible for the regulation/control of various hormone pathways in the body. One of these is the regulation of testosterone and dihydrotestosterone concentrati…
PI: Derry, William B
Cells that make up the tissues and organs of multicellular organisms must be maintained at a relatively constant number to maintain viability and prevent disease. If this intricate balancing act is t…
Identification and functional analysis of a novel metastasis-associated gene in prostate cancer
PI: Wang, Yuzhuo
Most deaths from prostate cancer (PCa) are due to metastases (cancer spread) in a form that is highly resistant to conventional therapies. There is an urgent need for more effective therapy to improv…
PI: Burrows, Lori L
Pseudomonas aeruginosa is a serious opportunistic and hospital-acquired pathogen, infecting burn, cancer, HIV and cystic fibrosis patients, as well as causing eye, ear and wound infections. It is rap…
Rapidly growing tumours contain many areas of low oxygen (hypoxia), and the presence of these hypoxic regions is associated with cancer metastasis and a poor clinical outcome. In a manner similar to …
PI: Kislinger, Thomas; Medin, Jeffrey A
Prostate cancer is the most common cancer among North American men and is in general treated by surgery, radiation therapy or chemotherapy. Cell-surface membrane proteins comprise more than half of t…
PI: Murphy, Paul R
Fibroblast growth factor (FGF) is a potent signaling molecule which promotes the growth of many kinds of cells. The expression of FGF is under tight regulatory control, and loss of this regulation ca…
PI: Nilson, Laura A
Our bodies contain a wide range of cell types that are specialized for carrying out particular functions. These cells adopt a variety of distinctive shapes, and are often organized into discrete tiss…
Herpesviruses are a large family of pathogens that infect and cause disease in diverse animals ranging from oysters to elephants. My laboratory studies the alphaherpesvirus subgroup that includes the…
PI: Chabot, Benoit
It takes 15 000 genes to make a fly and 10 000 more genes to make a human. The number of genes is therefore not a good predictor of the complexity of an organism. How is the complexity of the human b…
PI: Rousseau, Marie-Claude; Nicolau, Belinda F
Previous studies have shown that certain types of cancer begin as lesions appearing in different parts of the body. This study aims to investigate these lesions in the mouth and throat to determine w…
PI: Jones, Russell G
Cell division is a highly regulated process. The ability of a cell to successfully grow and divide partly depends on the cell having enough energy and building blocks to complete the task. Cancer is …
PI: Jones, Russell G
Cell division is a highly regulated process. The ability of a cell to successfully grow and divide partly depends on the cell having enough energy and building blocks to complete the task. Cancer is …
PI: Young, James D
A number of nucleoside analogs have anticancer activities and are either in current clinical use or in various stages of preclinical evaluation. Since the pharmacological targets of nucleoside drugs …
PI: Li, Gang
Cutaneous malignant melanoma is a life-threatening skin cancer due to its high metastatic potential. The mechanism behind the high invasive property and metastatic potential of melanoma is still inco…
Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer
PI: Mai, Sabine
We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus…
The recent success of Gleevec (imatinib) which targets the BCR-Abl protein kinase for the treatment of chronic myelogenous leukemia provides proof-of-principle for molecular-targeted therapy directed…
For some time we have used human adenoviruses as models to understand the molecular basis of cancer as such studies have provided many critical insights into processes of importance for cancer. In th…
Radiotherapy is an important form of treatment for cancer patients and has been shown to be useful in about 50% of patients with cancer. It can be used alone or in combination with chemotherapy or su…
Hepatitis B virus (HBV) is an important human pathogen implicated in a wide range of clinical manifestations, ranging from cirrhosis, liver cancer and hepatic failure to seemingly asymptomatic and un…
PI: Damha, Masad J
RNA interference (RNAi) is a natural cellular mechanism for selectively silencing the expression of genes via targeted mRNA degradation, preventing gene-coded protein production. Synthetic oligonucle…
Protein metabolism and insulin resistance in cancer cachexia: a potential anabolic role of leucine
Protein loss, mostly from muscle, is very common in lung cancer and this affects the patients' physical function, response to treatment and quality of life. We propose that cancer patients are losing…
PI: Sinnett, Daniel
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, but little is known about the cause(s) of this disease. We have shown that the origin of childhood ALL could be explained by th…
PI: Marshall, Jean S
A number of bacterial and viral products have been shown to reduce tumor growth in models of cancer and in clincal trials, however we have a poor understadning of how these work. Mast cells are immun…
PI: Spaner, David E
Chemotherapy does not cure most cancers. However, the results with chemotherapy may be improved with treatments that increase the ability of the immune system to kill cancer cells (or immunotherapy).…
PI: Cambrosio, Alberto; Keating, Peter
Promoters of genomic medicine, that is to say, medicine informed by the results of the recent mapping of the human genome, promise a revolution in all areas of clinical practice ranging from diagnosi…
The detection and repair of DNA damage are vital for cell viability. DNA repair defects lead to DNA translocations, deletions/ mutations, chromosome breakage leading to 'genomic instability' and canc…
Few interventions can help breast cancer patients improve their physical strength, stamina, and overall well-being during chemotherapy. Literature is now suggesting that physical activity (PA) is a s…
Few interventions can help breast cancer patients improve their physical strength, stamina, and overall well-being during chemotherapy. Literature is now suggesting that physical activity (PA) is a s…
PI: Deber, Charles M
Embedded in the membranes of all living cells, membrane proteins are the molecular links between the inside and outside world. These proteins help preserve the biological structure of the cells; they…
PI: Houry, Walid A
Hsp90 is a ubiquitous molecular chaperone that is found in eubacteria and all branches of eukarya. It plays a central role in cellular signaling since it is essential for maintaining the activity of …
The skeleton is very important for daily activities such as walking and posture. It is hence important for quality of life for an individual. Cancers that primarily arise within the bone or that have…
PI: Kaplan, Gilaad G
Crohn's disease and ulcerative colitis are incurable diseases that affect a patient's gut. The causes of these diseases are not known. However, it most commonly occurs in industrial countries such as…
PI: Rathee, Satyapal; Fallone, Biagio G
Nearly half of the cancer patients will receive radiation therapy for their treatment. Image guided radiotherapy promises to precisely align the diseased volume with the radiation beams in real time,…
PI: Brown, Grant W
Before a cell can grow and divide it must duplicate its DNA. In this way, when a cell divides to form two daughter cells, each of the daughters will receive the full complement of genes required for …
PI: Chen, Hsiao-Huei
Sensory neurons are frequently lost in patients with cancer, diabetes or HIV infection. Optimally, cell based therapies to selectively replace the missing sensory neurons will require knowledge of th…