CIHR Projects
Browse 2220 CIHR-funded research projects
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Showing 51-100 of 2220 projects
PI: Lau, Victor
Late-onset Alzheimer's disease (LOAD), which occurs after the age of 65 and comprises most cases of Alzheimer's disease involves progressive memory loss and neuronal cell death in the brain. As curre…
Nav-CARE is a volunteer navigation program that provides weekly visits and support to older adults with life-limiting illness who are living in the community. The purpose of my dissertation work is t…
PI: Dumchin, Nelly
The majority of cancer diagnoses in Canada occur in older adults. Aging is a risk factor for cancer and memory problems. Most patients with memory concerns or even those diagnosed with dementia can m…
PI: Wu, Che-Yuan
Dementia and cerebrovascular disease can lead to significant impact on everyday activities. The risk of dementia and cerebrovascular disease are linked to several chronic medical conditions emerging …
PI: Becker, Sara
Approximately 3-4% of adults over the age of 50 suffer from symptoms of attention-deficit/hyperactivity disorder (ADHD). Often, these symptoms present as cognitive deficits such as executive dysfunct…
PI: Menard, Alixe V
Pain diagnosis is a complex and challenging issue in residents living with dementia due to their difficulty verbalizing or self-reporting pain. It is not uncommon for pain diagnoses in residents livi…
The proposed research will work with individuals with dementia and their care partners to create a person-centred approach for routinely collecting information about the quality of life of people wit…
Managing the chronic effects of stroke (e.g., mobility issues, falls, pain, memory problems, depression) has become a global health priority due to its enormous burden on healthcare systems. A growin…
PI: Emdin, Abby L
My thesis applies emerging machine learning methods to identify common prescribing patterns over time to better describe potentially inappropriate prescribing and psychotropic medication exposures in…
PI: Tandon, Puneeta
Drastic social changes during COVID-19 have had a significant impact on the lives of older adults (aged 55+ years) with multiple chronic conditions. This group is at high risk of worsening mental hea…
PI: Giosa, Justine L; McNeil, Heather
The COVID-19 pandemic has worsened a pre-existing mental health crisis in Canada which has greatly affected older adults. It is critical that our health and social care systems are equipped to respon…
Depuis le début de la pandémie, 43% des Canadien·ne·s de 65 ans et plus ont rapporté un isolement et une solitude accrus, des facteurs exacerbant le stress, l'anxiété et la dépression. Comme la musiq…
Summer Program in Aging
PI: Jaiswal, Atul
I am a post-doctoral fellow in Vision Science at the School of Optometry, Université de Montréal. My research interests focus on sensory-cognitive aging and health, specifically aiming to overcome ba…
PI: Abolmaesumi, Purang; Tsang, Michael Y; Tsang, Teresa S
As the most prevalent and most deadly valvular heart disease, Aortic Stenosis (AS) is a significant public health problem in Canada. The prevalence of this valvular condition increases with age, with…
PI: Sale, Joanna E
A fragility fracture is one that happens after a slip, trip, or fall from standing height or less (for example, slipping on ice and breaking a wrist or hip). Over 131,000 Canadians have one of these …
It is increasingly important to find clues to maintain cognitive function, including the precise form of memory known as episodic memory, throughout aging. Our focus is on the hippocampus, the vital …
PI: Nguyen, Quoc Dinh; Wolfson, Christina M
Vital signs are used everyday by healthcare professionals to quickly screen and assess the health status of patients. Heart rate, blood pressure, temperature, respiratory rate, and blood oxygen level…
PI: Hoben, Matthias; Estabrooks, Carole Anne; Jarrett, Pamela
Quality of life (QoL) is the ultimate goal of care for people living with dementia in long-term care (LTC). Nine out of 10 LTC residents have dementia or significant memory problems - and often they …
PI: Patel, Tejal; Lee, Linda
The goal of the current proposal is to bring together a team of researchers, physicians, pharmacists, health sector administrators and persons with memory disorders and their care-partners to brain-s…
PI: Gan, Daniel R
Where we live affects cognitive decline. Neighbourhood deprivation is correlated with smaller hippocampal volume at death, even after controlling for race and individual socioeconomic status (Hunt et…
PI: Aumont, Étienne
Dans la maladie d'Alzheimer il existe une atteinte des neurones produisant l'acétylcholine, un messager chimique du cerveau. Toutefois, il existe une controverse quant au moment précis où apparait ce…
PI: To-Miles, Flora
Background: With over 55 million people living with dementia worldwide, this disease has significant impacts for residents living in long-term care (LTC) settings. Augmented reality (AR) and Virtual …
PI: Rochon, Paula A; Huynh, Tai; Ivers, Noah M; Savage, Rachel
Many older adults live clustered in buildings or communities, known as Naturally Occurring Retirement Communities (NORCs). These communities provide an opportunity to deliver on-site social supports …
PI: Muscedere, John; Desjardins, Craig; Collins, Patricia A; Depaul, Vincent G; Dionne, Emilie; Donnelly, Catherine A; Giguère, Anik; Guillaumie, Laurence; Hirdes, John P; Puchalski Ritchie, Lisa M; Puxty, John; Visvanathan, Renuka
Canadians are living longer but many have reduced quality of life and trouble with day-to-day activities, and often develop frailty. Older adults with frailty are vulnerable to catastrophic decreases…
PI: Mckay, Heather A; Tosdevine-Tataryn, Sahra-Lea; Havaei, Farinaz; Mackey, Dawn C; Sims Gould, Joanie
As one-third of Canadians will be older adults (>65y) by 2050, it is no surprise that healthy aging is a public health priority. Older adults who are physically active are more socially connected and…
Zoomers on the Go: Implementation of a Peer-Led Exercise Program for Falls-Prevention Across Canada
PI: Bouchard, Danielle; Louis, Richard; Kehler, Dustin S; Sénéchal, Martin; Sibley, Kathryn M
Many Canadian adults fall every year. The consequences can be catastrophic for older adults, including being hospitalized for long periods and moving to a long-term care facility. In some cases, fall…
PI: Agarwal, Gina (Ragini); Poll, Amy; Dunn, James R; Wyndham-West, Catherine M
There are many groups of people who experience aging differently due to their race, ethnicity, immigration status, income, or other factors. One reason is that they often face additional barriers in …
PI: Vedel, Isabelle; Arsenault-Lapierre, Genevieve; Bergman, Howard; Couturier, Yves; Godard-Sebillotte, Claire; Massamba, Victoria K; Quesnel-Vallée, Amélie; Sourial, Nadia
The restrictions put in place during the COVID-19 pandemic by many governments to contain the spread of COVID-19 revealed challenges within the health care system, specifically for people with Alzhei…
Bitter-sweet role of glucose: Uncovering the dynamic of transient hyperglycemia-mediated longevity.
Hyperglycemia (high glucose concentration) is associated with metabolic and age-related disorders. Chronic hyperglycemia is responsible for insulin resistance, obesity, hypertension, and neuropathies…
PI: Keefe, Janice M
Persons aged 85 and older are a fast-growing population group in Canada and worldwide. Often referred to as the "oldest old', this group will continue to grow in the future as the first baby boomers …
PI: Pasquier, Jean Charles; Plourde, MĂ©lanie; Ramanathan, Sheela
Les personnes âgées, qui ont souvent une santé plus fragile, ont été particulièrement touchées par la pandémie COVID-19. Les résultats des études récentes montrent que, si les vaccins ont présenté un…
PI: Hoben, Matthias; Maxwell, Colleen J
COVID-19 has had a devastating impact on older adults living in long-term care (LTC) & assisted living (AL). Residents in these settings experienced higher rates of COVID-19 infection and more seriou…
PI: Walmsley, Sharon L; Gingras, Anne-Claude; Rochon, Paula A
There has been rapid approval of the COVID-19 vaccines. The participants in the initial research were mostly Caucasian with an average age of 50 years and with little underlying illness. More informa…
PI: Proulx, Camille
The majority of people who sustain a stroke have partial or complete paralysis of one hand which causes difficulty in performing daily activities. These difficulties often continue even after complet…
L'apnée du sommeil comme facteur de risque de déclin cognitif chez les hommes et les femmes
PI: Legault, Julie
Des études récentes suggèrent qu'un mauvais sommeil peut augmenter les risques de démence. En effet, un mauvais sommeil augmenterait la production de bêta-amyloïdes, une protéine impliquée dans la ma…
Metformin administration restores depleted NAD levels to improve outcomes in elderly burn patients
PI: Barayan, Dalia
Severe burns account for an estimated 330,000 deaths per year worldwide- ranking fourth in incidence among all forms of trauma. While modern burn care has markedly improved survival for pediatric and…
PI: Ahmad, Fayeza
Frailty is the body's inability to respond well to stressors in aging patients. Sarcopenia means having less muscle and less strength in the body. Having decreased amount of muscle and strength can l…
PI: Traa, Annika
Aging is the greatest risk factor for age-related diseases such as cancer, diabetes, cardiovascular disease, and neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's disease. …
PI: Cumal, Alexia A
Background: Older people with dementia frequently go to the hospital and stay there for long periods of time. In Ontario, transitional care programs (TCPs) - facilities that provide short-term care t…
PI: Poirier, Stefan
Ischemic heart disease (IHD) patients who have had a recent heart attack are at serious risk of developing cognitive impairment which, without proper intervention, can lead to depression and poor qua…
PI: McMenemy, Claire
Caregivers of community-dwelling Persons with Dementia (PwD) often experience a high burden of care that is associated with increased risks to their own health and that of the PwD, and with higher so…
PI: Broberg, Dana N
Difficulty speaking is a common problem experienced by people with brain diseases that lead to dementia. Speech involving whole phrases rather than individual words (called connected speech) provides…
PI: Kervin, Lucy M
Canada's caregiving landscape is shifting. Increased longevity, declines in marriage, and rises in divorce and family mobility may negatively impact the availability of informal or family-based elder…
PI: Banga, Shubham
Heart disease is a leading cause of death worldwide and is a great challenge for our aging population. Testosterone levels decline with age in both men and women, while the risk of heart disease incr…
PI: Quach, Hoang
Cardiovascular disease (CVD) involve problems of the heart or blood vessels. CVDs affect one in three older adults, making it a leading cause of death in Canada. Often, those living with CVD also hav…
PI: Kropf, Erika
The brain cells that are critical for learning, memory, and attention lose function with age and die in Alzheimer's disease, causing memory decline. These cells obtain the proteins they need to survi…
PI: Dash, Darly
The COVID-19 pandemic shows the threat to older adults, especially residents living in nursing homes. Residents living in nursing homes are impacted by the care practices delivered by their physician…
PI: Sharma, Nilesh
Alzheimer's disease is a devastating illness which results in memory loss, inability to think clearly and other abnormalities. Specialized cells in the brain, called ependymal cells, begin to accumul…
Assisted Living Communities (ALCs) function as private, public and healthcare spaces. Older adults in ALCs make their homes, share community resources and receive medical care in the same space. In A…