CIHR Projects
Browse 3998 CIHR-funded research projects
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PI: Leung, Brendan M
Chemotherapy induced oral mucositis (CIOM) is a painful and debilitating side effect of cancer treatment that affects 20-40% of cancer patients. Chemotherapy kills cancer cells, but it also affects f…
The role of the RNA helicase DDX3X in Burkitt Lymphoma and its potential as a new therapeutic target
PI: Moroy, Tarik
Burkitt lymphoma is a blood cancer, which manifests itself as masses of tissue in the neck or jaw, often disfiguring the patients. This disease occurs very frequently in children and is treated by su…
PI: Karsan, Aly
Acute myeloid leukemia (AML) is a very aggressive cancer. The median age of AML patients is 68 years old, and only 10% of those over age 60 survive this cancer. AML is initiated and maintained in pat…
Fate and function of mesenchymal progenitors within the medulloblastoma tumour microenvironment
Medulloblastoma (MB) is the most prevalent malignant brain cancer in children. Some forms are highly metastatic, and infiltrate the brain and spinal cord, leading to severe morbidity. Molecular chara…
PI: Meloche, Sylvain
The development of selective chemical inhibitors of protein kinases is of key importance for understanding kinase mechanisms and exploring their roles in physiology and disease. These chemical tools …
PI: Talhouk, Aline; Anglesio, Michael S; Hill, Janet E; Money, Deborah M; Tinker, Anna
Endometrial cancer is the most common gynecological cancer in Canada and the developed world. Individuals with a uterus experience changes in bleeding as they age, that can be the first sign of endom…
PI: Topisirovic, Ivan; Ferbeyre, Gerardo
Unlike normal cells, cancer cells must support constant growth while being exposed to extreme fluctuations in nutrient and oxygen availability. To achieve this, cancer cells rewire their metabolic pr…
Metastatic cancers are the most aggressive cancers, accounting for 90% of all cancer-related deaths. Radiation as well as chemotherapy are not effective enough to fight against these types of cancers…
The number of new cancer cases in Canada continues to increase annually, (in part) due to our growing aging population. The Canadian Cancer Society estimated that between 2015 and 2030, new cases of …
Behaviour-based cell separation to interrogate host cell heterogeneity in CAR-T cell therapies
PI: Ma, Hongshen
Chimeric antigen receptor cell therapy is a new form of cancer therapy that modifies a patient's own immune cells in order to give them the ability to eliminate cancer cells. These therapies have bee…
Regulation and function of NFE2L3: linking transcription factor activity to colorectal cancer
PI: Blank, Volker
Transcription factors are important molecules that control whether genes are active or not in a specific cell within an organism. Our research focuses on the functions of the CNC transcription factor…
Exploring the therapeutic potential of combined inhibition of MNK1/2 and CDK4/6 to treat melanoma.
PI: Miller, Wilson H
Drugs that activate the immune system have provided dramatic improvements in response and overall survival to a growing number of deadly malignancies. Unfortunately, these therapies do not work in al…
PI: Olson, Robert A; Schellenberg, Devin; Palma, David
Background: Oligometastatic disease refers to a state where cancer has spread beyond the site of origin but is not widely metastatic (defined variably between 1-5 metastases). In this state, it is hy…
PI: Gamper, Armin
With nearly half of Canadians expected to be diagnosed with cancer during their life time, cancer is a disease that unfortunately is only too familiar with us. Due to demographic shifts the incidence…
Cancers have been the leading cause of death in Canada at least since the early 2000s. The built environment is the infrastructure and its layout made by humans such as urban green spaces, road netwo…
PI: Liang, Kevin
Whether it be in the food we eat, the water we drink, or the things we encounter daily, toxins (e.g., lead, cadmium, and BPA) in varying amounts and kinds are often ingested. As such, regardless of o…
PI: Tinmouth, Jill M; Heitman, Steven J; Urquhart, Robin L
Colorectal cancer (CRC) is a leading cause of death which can be prevented by screening. Cancer screening is testing done on people who are at risk of getting cancer, but who have no symptoms and gen…
PI: Morin, Ryan D
Cancers that arise from cells of the immune system are broadly divided into leukemias and lymphomas and the latter forms solid tumours at various places in the body. The most common variety of lympho…
We are requesting funding for the 37th annual meeting of the Canadian Association of Psychosocial Oncology (CAPO) which will be held in collaboration with the International Psychosocial Oncology Soci…
Each year in Canada approximately 13,000 new people are diagnosed with gynecologic cancer. The science has greatly advanced such that more patients are surviving these gynecologic cancers. However, t…
Senescence is an anticancer response that involves loss of proliferation and secretion of pro-inflammatory mediators that engage the immune system for the clearance of senescent cells. Senescence is …
Boron Neutron Capture Therapy in Canada: Establishing research directions priorities and strategies.
Over 80% of the projected 3000 Canadians who were diagnosed in 2020 with cancer in the brain or central nervous system will die from it. Boron Neutron Capture Therapy (BNCT) is a radiation therapy th…
PI: Mann, Koren K
The 11th Conference on Metal Toxicity and Carcinogenesis will be held in Montreal from October 18-21, 2020. This conference brings together scientists from around the world and many sectors, includin…
MAppinG adaptatioN Of tripLe negative breast cancer microenvironments to ImmunotherApy (MAGNOLIA)
PI: Park, Morag; Stagg, John
Worldwide, 1 in 8 women will develop breast cancer in the course of their lifetime. Triple-negative breast cancers (TNBC) represent 15-20% of all diagnosed breast cancers and are associated with earl…
PI: Rak, Janusz
The presently incurable brain cancer, called glioblastoma (GBM), triggers formation of strange blood vessels, which play a role in disease progression as a source of nutrients, stimulants, and tracks…
PI: Quail, Daniela
Cancer immunotherapy has revolutionized cancer care, but its efficacy is dependent on the presence and activity of T cells within the tumor. We have discovered a unique immune cell type that consumes…
PI: Daniel, Juliet M
The COVID-19 pandemic has placed increasing demands on healthcare services globally with cancelled or delayed surgeries, and ICU capacity limits exceeded in many regions. Unfortunately, many Black an…
PI: Goodarzi, Aaron
Our goal is to understand and address rising radon gas-induced lung cancer risks due to COVID-19 pandemic-linked lung injury, disability, and behaviour change. 1 in 5 lung cancers arise in Canadians …
The COVID-19 pandemic caused major disruptions to cancer control and care services in Canada. Patients with cancer are at a particularly high risk of negative outcomes from delays in diagnosis and tr…
PI: Cil, Tulin D; Eskander, Antoine; Zhong, Toni
INTRODUCTION: During the COVID-19 pandemic, there were limitations in healthcare resources which led to restricted access to breast cancer screening and treatment. These limitations have the potentia…
PI: Eskander, Antoine; Sutradhar, Rinku
The COVID-19 pandemic has transformed Canada's cancer system. Beyond short-term disruptions on care delivery, wider and long-term impacts, arising from cancer screening delays, prolonged wait times f…
PI: Lin, Kuo-Shyan
Cancer is a deadly disease and the leading cause of death worldwide. As early detection and treatment can greatly improve patient outcomes, better diagnostic and therapeutic agents are urgently neede…
PI: Rose, April A
Metastatic melanoma is a devastating and deadly disease. Fortunately, great strides have been made in the treatment of melanoma and a number of effective treatments are now available to patients. Som…
Breast cancer is the most common and one of the deadliest cancers affecting women in North America. One group of breast cancers is called the triple-negative breast cancer and comprises highly aggres…
PI: Sharif, Tanveer
In Canada, approximately 1,400 children are diagnosed with cancer each year and approximately 30% of those have a brain tumor. Brain tumors are now the leading cause of cancer-related death in childr…
PI: Bahig, Houda
Patients undergoing radiotherapy have daily images to verify their positioning before treatment delivery. As can be routinely observed in the clinic, these images often demonstrate important anatomic…
PI: Yauk, Carole L
The International Conference on Environmental Mutagens (ICEM) is convened every four years and is the largest gathering of scientists working in the field of environmental mutagenesis. Mutagenesis is…
Discoveries in the field of immunotherapy have been rapidly accelerating, entering the forefront as a leading area of cancer research and delivering novel therapeutics that have revolutionized the tr…
PI: Levesque, Ariane
Saviez-vous que plus d'un enfant sur deux qui survit à un cancer pédiatrique souffrira de symptômes invalidants liés à son cancer à un moment ou l'autre de sa vie? Depuis les dernières décennies, les…
Lymphoma is the 6th most common form of cancer in Canada, with one in 38 Canadians expected to develop lymphoma during their lifetime. While advances in treatment options over the past two decades ha…
Multiple myeloma (MM) is a prevalent and incurable blood cancer with poor prognosis and a high rate of relapse. It presents a dire unmet need in its understanding as a disease and an urgency to impro…
PI: Chan, Ace Y
About 50% of cancer diagnoses are preventable by adopting healthy lifestyle behaviours such as limiting the consumption of alcohol and tobacco. World-renowned cancer research organizations have repor…
Cancer cells exhibit large differences in metabolism compared to healthy cells, particularly in how certain nutrients are used as fuel by cancer cells. Cancer cells not only have unique demands for s…
Protein trapping for therapeutic targeting of WRN in cancers with microsatellite instability.
Despite many advances in cancer treatment, it is challenging to selectively kill cancer without harming normal tissue. Cancer cells have high levels of DNA damage, relying on DNA repair to survive. T…
Identification of polysialylated proteins in breast cancer and correlation with patient prognosis
Breast cancer is the leading cause of cancer-related deaths in women worldwide. Metastasis, which is the spread of cancer cells from a primary tumor to other areas in the body, remains the main cause…
PI: Reisle, Caralyn
Tailoring treatment to an individual's genetic profile through precision oncology has played an increasing role in cancer treatment over the last decade. Research has shown that there is value in app…
Hematopoietic Stem Cell Transplantation (HSCT), the infusion of a donor's immune system into a recipient, is an important immune-based therapy for patients with high-risk and recurring blood cancers.…
PI: Keshavarz, Faeze
The modifications in exonic regions of DNA (parts of DNA sequence that are translated to proteins) can affect the structure and consequently the function of proteins and the cellular pathways they pa…
PI: Yao, Fupan
Atypical Teratoid Rhabdoid Tumors (ATRTs) are rare brain tumors of young children under the age of 3. ATRTs tumours are unique in that they only lose one gene, SMARCB1, and have one of the lowest mut…
PI: Lubanszky, Evan
Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating disease that is the leading cause of brain-tumour related death in children, for which there is no effective treatment. There are many factors…