CIHR Projects
Browse 977 CIHR-funded research projects
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PI: Morin, Melanie
Chronic vulvar pain is a highly prevalent and debilitating condition affecting up to 18% of women. The most common subtype of vulvar pain, provoked vestibulodynia (PVD), is characterized by a sharp p…
PI: Logie, Carmen; Mbuagbaw, Lawrence C; Obbuyi, Albert
THE ISSUE: Global regions most impacted by HIV are also greatly affected by climate change and extreme weather events (EWE), such as droughts and floods. Yet the pathways linking climate change and E…
With the relaxation of cannabis restrictions across North America, there has been a significant increase in the proportion of young adults (19-30 yrs of age) who report using marijuana. While the use…
PI: Barata, Paula C; Docherty, Lieran
Stay-at-home orders that were put in place during the COVID-19 pandemic put some families at greater risk. For example, victims of family violence would find it difficult to access supports if the ab…
PI: Lachowsky, Nathan J; Gahagan, Jacqueline C; Gupta, Neeru; Jollimore, Jody
The federal parliamentary Standing Committee on Health called for better data practice to address health inequities among Two-Spirit, lesbian, gay, bisexual, trans, queer, questioning, intersex, and …
Lil'wat Medicine Shed: Supporting Traditional Medicine Usage and Traditional Knowings of Gender
PI: Bulkan, Janette
The traditional medicines of the Lil'wat Nation have a gendered aspect, with traditional roles, ceremonies and medicines being associated with gender identities and roles. However, there is an increa…
PI: Salway, Travis; Pruden, Harlan
Two-Spirit Dry Lab (2SDL), Turtle Island's first research group that exclusively focuses on Two-Spirit people, communities, and experiences, is collaborative of Indigenous and settler researchers and…
PI: Newman, Peter A; Dubey, Vinita; Massaquoi, Notisha M
The rapid development of COVID-19 vaccines is a huge scientific achievement; to be effective, however, people must get the vaccine. With disparities in COVID-19 infections and severe disease outcomes…
PI: Juster, Robert P
The COVID-19 pandemic has been especially distressing for members of Canada's lesbian, gay, bisexual, transgender, queer, intersex, and two-spirit (LGBTQI2S+) communities. Due to stigma and social is…
PI: Bhat, Mamatha; WANG, BO; Xu, Wei
The current organ allocation system for liver transplantation (LT) was developed to prioritize the sickest patients and improve equality. However, access to LT has remained compromised among women an…
PI: Kovalchuk, Olga
Based on the estimates of the WHO, one in 5 men and one in 6 women worldwide will develop cancer during their lifetime, and by the end of 2020 there will be over 70 million cancer survivors worldwide…
PI: Salway, Travis
Over the course of recent decades, Canadian federal, provincial, and territorial governments have enacted laws to protect the rights and well-being of lesbian, gay, bisexual, transgender, queer, and …
PI: Pritlove, Cheryl
Early emerging adulthood (18 to 24 years) is a time of emotional, psychological and social change, and for those living with type 1 diabetes, represents a period of life that is often associated with…
Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes.
Urologic and gynecologic patients often have problems requiring surgical reconstruction to recreate a normal function, notably for vaginal reconstruction and for the correction of stress urinary inco…
PI: Scott-Storey, Kelly; O'Donnell, Susanne M
Violence is a major public health problem. Men experience and commit many forms of violence across their lifetime at home, in workplaces, and in public, yet we know little about the health effects of…
Pain in the genital and/or pelvic regions ("genitopelvic pain") affects between 14-27% of people and can have a significant impact on one's mood, relationship, and quality of life. Sexuality is often…
La pandémie de COVID-19 a mis en exergue les différences de genre qui persistent au niveau de la conciliation travail-famille, et ce, malgré des années de progrès social dans la poursuite de l'équité…
PI: Parks, Robin J
Spinal muscular atrophy (SMA) is a devastating disorder primarily affecting newborns and young children. It is caused by reduced levels of the survival motor neuron (SMN) protein. Although normally p…
PI: MacEachen, Ellen
Gig courier workers, such as Uber Eats, Amazon Flex, and Lyft drivers, have been busier than ever during the Canadian COVID-19 pandemic as the public attempts to avoid illness by ordering take-away f…
Haiti is one of the most food insecure countries in the world: 80% of rural dwellers are food insecure; and although women play a central role in agriculture, they disproportionately suffer from food…
PI: Henry, Richard S
Trans and non-binary (TGNB) individuals face barriers to receiving health care and experience high rates of mental health issues linked to stigma and discrimination. "Trans" is an umbrella term for p…
Postpartum depression is common, affecting about 10-15% of Canadian women, and is associated with increased risk for suicide, particularly in severe cases. Postpartum psychosis - whereby women discon…
PI: Lauzon-Joset, Jean-François
Psychological stress can reshape how the brain communicates with our immune system. We have reasons to believe that psychological stress occurring soon after birth rewires the immune system different…
PI: Mishra, Suresh
Fat cell and immune cell functions undergo parallel changes in the body during various stages of life in health and disease. The most notable examples are puberty, pregnancy, and menopause, as well a…
Sexual dimorphism and menopause in the interaction between immune cells and neurovascular coupling
The increase in cerebral blood flow produced by neural activity (neurovascular coupling), a critical mechanism that matches substrate delivery with energy demands in brain is modulated by circulating…
PI: Logie, Carmen; Juster, Robert P
THE ISSUE: There are more than 79.5 million forcibly displaced persons across the globe who experience a disproportionately high prevalence of mental health issues. Forty percent of the world's refug…
With the relaxation of cannabis restrictions across North America, a growing proportion of young adults (19-30 yrs of age) are reporting the Simultaneous use of Alcohol and Cannabis. The use of legal…
PI: Sloboda, Deborah M; Beristain, Alexander G
Maternal factors, including obesity, increase the risk of obesity in her offspring - independent of postnatal diet and lifestyle - in a sex-specific manner where males and females show different meta…
PI: Law, Susan K; Code, Jillianne; Smilovitch, Mark
Women with heart failure (HF) do not always receive the best care possible in part because of issues related to their sex and gender. The overall goal for this project is to improve the experiences a…
PI: Peters, Cheryl E
Workplace exposure to hazardous substances (such as asbestos, radiation, and some chemicals) is an important and preventable cause of disease in Canada. Exposure to occupational carcinogens alone lea…
PI: Knight, Rodney E; Ferlatte, Olivier
Sexual and gender minority (SGM) youth (15-24 years old) experience higher rates of substance use (including cannabis) and mental health and illness-related problems than their heterosexual and cisge…
With aging, the aortic valve calcifies, thus the opening of the valve decreases, blocking the ejection of the blood in the body: this is aortic stenosis. Aortic stenosis is the most common cardiovasc…
In Canada as of 2019, a woman's life expectancy is 4 years longer than a man's. However, when a woman is HIV-positive, not only is her life expectancy 5-10 years shorter than other women her age who …
PI: Chaiton, Michael O; Yager, Christina M; Abramovich, Alex
Youth and young adult serving organizations are facing numerous challenges meeting the needs of youth during the COVID-19 pandemic. Many services typically available to youth in crisis have had to cl…
PI: MacEachen, Ellen
Gig courier workers, such as Uber Eats, Amazon Flex, and Lyft drivers, have been busier than ever during the Canadian COVID-19 pandemic as the public attempts to avoid illness by ordering take-away f…
PI: Newman, Peter A; Chakrapani, Venkatesan; Phanuphak, Nittaya
The extreme global impact and still uncertain path of COVID-19 demands collaboration among researchers and communities in high- (HIC) and low-income countries (LMIC) to effectively halt the pandemic.…
PI: Logie, Carmen; Hakiza, Robert
THE ISSUE: Poverty, overcrowded living conditions, and poor sanitation increase COVID-19 risks in humanitarian settings while limiting the ability to practice prevention strategies (e.g. physical dis…
PI: Parry, Monica J; Bjoernnes, Ann K
The overall goal of this project is to develop a population-based program to improve the mental health and well-being in family carers of COVID-19. In order to do this quickly and properly, we have d…
PI: Greaves, Lorraine J; Poole, Nancy
With greater social isolation, stress and uncertainty during COVID-19, the risk of intimate partner violence (IPV) and substance use among women has increased. In Canada, there have been more IPV rel…
PI: Greaves, Lorraine J; Poole, Nancy
Vaping during pregnancy and postpartum is under-investigated, resulting in little evidence on which to develop advice for women and practitioners. Vaping can involve either nicotine and/or cannabis, …
PI: Brennand, Erin A
Pelvic organ prolapse (POP) is a medical condition in females where pelvic organs, such as the uterus or intestines, fall out of normal position and press into the vagina. POP will affect up to half …
Many differences between males and females arise between conception and birth. As the main regulator of fetal growth and development is the placenta, many of these differences arise because male and …
PI: Juster, Robert P
This CIHR Chair on LGBTQI2S Wellness and Resilience aims to study stress biology, mental health, and resilience of lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people across adulthood. To …
PI: Lai, Meng-Chuan
Neurodevelopmental disorders (NDD), characterized by early-onset atypical behaviour and brain development, are relatively common and constitute a critical, but often overlooked, developmental backgro…
PI: Bauer, Greta R
Epidemiologists design and conduct quantitative studies that measure health outcomes and use complex statistics for analysis. The overarching goal of the proposed program is to strengthen the methods…
PI: Shannon, Kate
Gender transformative sexual health care for youth (15-29 years) remains a pressing issue across Canada. In BC, rates of STIs, sexual violence, and unplanned pregnancies among youth remain alarmingly…
PI: Klassen, Anne F
Children and youth who are gender-affirming are increasingly seeking acces to transgender health services. Hormone blockers, gender-affirming hormones and transgender surgery can help pediatric patie…
Understanding and mitigating real-time differential gendered effects of the COVID-19 outbreak
PI: Lee, Kelley; Smith, Julia; Wenham, Clare
Infectious disease outbreaks are considered by policymakers as global, collective problems, assuming a similar impact of pathogens on all people. Yet, the impact of disease on individuals and communi…
PI: Zeller, Michelle P; Heddle, Nancy M
Red blood cell (RBC) transfusions are selected based upon donor and recipient blood group compatibility: donor and recipient sex are not factored into the selection of compatible blood.This study wil…
PI: Lalu, Manoj M; Fergusson, Dean A; Fiest, Kirsten M; Fox-Robichaud, Alison E; Gill, Sean E; Liaw, Patricia C; Macala, Kimberly; McDonald, Braedon A
Many differences exist between men and women when it comes to how diseases affect the body, and how effective treatments for those disease are. Despite this, medical research has demonstrated a lack …