CIHR Projects
Browse 1992 CIHR-funded research projects
Search & Filter Projects
Showing 51-100 of 1992 projects
PI: Guilcher, Sara J; Hitzig, Sander L
Approximately one in five Canadians over the age of 15 experience one or more disabilities, with more people experiencing disability as they age. Physical disabilities are the most commonly reported …
Rheumatology is the medical specialty dedicated to providing healthcare to persons who have autoimmune inflammatory arthritis conditions, including rheumatoid arthritis (RA), psoriatic arthritis (PsA…
PI: Flynn, Lauren E
While often regarded negatively, the adipose tissue (fat) layer within the skin plays a critical role in defining the natural contours of the human body. Following damage or injury, these tissues hav…
A large percentage of the general population is affected by periodontal diseases. Associated with this inflammation is loss of tooth-supporting bone and, if severe, loss of teeth and ultimately funct…
Spinal disorders as a result of aging, trauma, deformity and cancer cause significant pain and disability and often require surgical intervention for effective treatment. These reconstructive surgeri…
PI: Leask, Andrew C
Fibrotic diseases such as scleroderma have no therapy. These diseases are characterized by extensive scar tissue deposition. The cells (fibroblasts) within the scar are subject to enhanced tension du…
There are many diseases that result in an increase in the amount of extracellular matrix, making the skin hard and inelastic. Among these diseases, scleroderma and hypertrophic scars are two disablin…
Musculoskeletal disorders (MSKd) have a significant impact on soldiers as they lead to restricted duties, sick leave, and inability to deploy. Their high prevalence is plaguing modern armies and slow…
PI: Hall, Derek T
Maintenance of muscle through muscle regeneration is a critical aspect of human health. Indeed, defects in muscle regeneration are associated with numerous muscle-related diseases, such as muscular d…
PI: Wong, Jessica
At least one in three people (2.4 billion people) globally will require rehabilitation at some point in their life, and the need for rehabilitation is increasing. However, this increasing need for re…
PI: Gatti, Anthony A
Osteoarthritis is the leading cause of disability in older adults and costs Canada $27 billion/year. Osteoarthritis is a chronic disease that causes degeneration of all tissues in the knee. Individua…
PI: Dima, Robert
Osteoarthritis (OA) is the most common joint disease, worldwide affecting 9.6% of men and 18.0% of women over 60 years old, and is a major source of disability, pain, and socioeconomic cost. Recent i…
PI: Ramzan, Firyal
Amyotrophic Lateral Sclerosis (ALS) affects roughly 3000 Canadians, and patients typically die within 2-5 years of diagnosis. Roughly 1000 Canadians die from ALS, and a similar number are diagnosed e…
Unravelling the underlying mechanisms of male chronic pelvic pain to develop personalized management
Chronic prostatitis/chronic pelvic pain syndrome is the leading genitourinary condition in men. It is characterized by pain experienced in the perineum, genitalia, bladder or prostate for more than 3…
PI: Wong, Jessica
At least one in three people (2.4 billion people) globally will require rehabilitation at some point in their life, and the need for rehabilitation is increasing. However, this increasing need for re…
Unravelling the underlying mechanisms of male chronic pelvic pain to develop personalized management
Urologic chronic pelvic pain syndrome is the leading genitourinary condition in men. It is characterized by pain experienced in the perineum, genitalia, bladder or prostate for more than three months…
Myotonic dystrophy type 1 (DM1) is a genetically inherited disease, characterized by progressive dysfunction of multiple organs. While DM1 affects many body functions, including the heart, lungs and …
PI: Mourad, Walid M
Systemic lupus erythematosus (SLE) is an autoimmune condition where the body's immune system attacks its own cells and tissues. There is no cure yet and available medications can only help to control…
Arthritis is a collection of more than 100 debilitating diseases affecting the joints and surrounding tissues leading to progressive dysfunction of the affected joints and causing an incredible burde…
PI: Ghahary, Aziz
Patients with burns and large wounds need skin grafts to survive. The grafted skin should ideally come from the same patient to avoid the risk of being destroyed by the immune system. However, there …
Bone mass can decline up to 50% in the first 12-18 months after a spinal cord injury (SCI). Weaker bones increase the risk of fractures. Bone fractures in the hip or knee region can result in illness…
PI: Sone, Eli D
Periodontal disease is the most common infection in Canadian adults, and incidence is expected to increase as the population ages. In this disease, the attachment of teeth to the jawbone is destroyed…
Engineering bioactive dressings from mesenchymal cells to enhance healing of irradiated skin wounds
PI: Fradette, Julie
Radiotherapy is effective for cancer treatment but it can produce incapacitating and difficult-to-heal skin wounds as a side effect. An approach currently being explored to promote healing is the use…
PI: Chan, An-Wen; Kim, Sang J
As patients live longer after receiving an organ transplant, there is a need to reduce the long-term side effects of the drugs used to prevent organ rejection. In particular, long-term use of these d…
PI: Germain, Lucie
Ce projet fait partie de mes recherches en Cellules Souches et Génie Tissulaire visant à reconstruire des organes humains en laboratoire dans le Centre de Recherche en Organogénèse Expérimentale de l…
Osteosarcopenia is the loss of both muscle mass (sarcopenia) and bone mass (osteoporosis). Osteosarcopenia commonly occurs in cancer patients due to both the presence of cancer and as a collateral ef…
PI: Beier, Frank
Osteoarthritis (OA) is the most common form of arthritis and affects more than 4 million Canadians. The impacts of OA on affected patients and the society are enormous, both in terms of individual su…
PI: Khan, Mohammed M; Degen, Ryan M
Shoulder dislocations are a common and potentially devastating injury affecting with a global incidence that is estimated to be over 24 per 100,000 people. Dislocations primarily affect young active …
PI: Wither, Joan E
In lupus, antibodies are mistakenly produced against molecules that are part of the body, such as DNA and other proteins found in the nuclei of cells (ANAs), which then deposit in the organs causing …
PI: Oxland, Thomas R
Up to 2/3 of adults over the age of 65 years will develop some form of spinal deformity. The most severe cases will require surgery to help relieve pain and improve function. While mostly successful,…
Using a novel method to diagnose the prevalence and health impact of muscle loss in older adults
PI: Phillips, Stuart M; Beauchamp, Marla K; Kirkpatrick, Sharon; Mayhew, Alexandra J; McKendry, James; McMillan, Jacqueline M; McNicholas, Paul D; Prado, Carla M; Raina, Parminder S
The concept of declining function with age requires a better understanding of whether it is an immutable characteristic of aging or whether it can be mitigated. When we age, we lose muscle. However, …
PI: Hazlewood, Glen S; Wells, George A
Rheumatoid arthritis is a chronic autoimmune form of arthritis that can affect adults of any age. People living with rheumatoid arthritis experience pain and swelling in their joints, fatigue, and di…
Osteoarthritis is a chronic disease of the joints with no available disease modifying treatments. The changes that happen when a knee joint goes from being healthy to arthritic are not completely und…
PI: Krawetz, Roman J
Throughout the lifespan, bone remodels in response to damage, such as fracture. However, diseases such as osteoporosis can cause impaired bone healing, increasing the risk of progression to non-repai…
PI: Kolta, Arlette
Repetitive movements like walking, breathing and chewing insure vital functions and are produced by more primitive areas of the brain. Although these movements are executed with a high level of autom…
Osteoporosis is a disease where an individual's bone density is reduced, which decreases its strength and increases the risk of a fragility fracture. This disease is common in older adults and is the…
PI: Fahmi, Hassan
Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability in Canada and worldwide. It has a large impact on the patient's quality of life, and constitutes a significa…
PI: Antoniou, John; Mwale, Fackson
Osteoarthritis (OA) is the most common chronic condition of the joints, and a leading cause of pain and disability worldwide. It is the fourth most common cause for hospitalizations and a leading ind…
Regeneration at your fingertips: mechanisms determining mesenchymal tissue repair versus fibrosis
PI: Miller, Freda D
The finding that some animals can regenerate lost body parts has fascinated scientists for centuries. However, the ability to regenerate varies widely; some amphibians can regenerate entire limbs, wh…
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women.
PI: Gagnon, Claudia; Langlois, Marie-France; Morin, Suzanne N
Background: Sleeve gastrectomy bariatric surgery for the treatment of obesity is increasingly popular in Canada, and this trend is unlikely to abate. Older bariatric procedures that reduce absorption…
PI: Roy, Jean-SĂ©bastien; Paquette, Jean-SĂ©bastien; Perreault, Kadija
Of the 1,000,000 Canadians who have been infected by COVID-19, 8 to 15% will continue to experience COVID-19 related symptoms well after 12 weeks. The persistence of such symptoms is now defined as "…
PI: Nacul, Luis; Levin, Adeera; Mckay, Rhonda J; Song, Xiaowei
This study aims to determine whether low-dose naltrexone (LDN) improves energy and reduces fatigue and pain in people who had COVID-19 (i.e. confirmed SARS-COV-2 positive) and have persistent symptom…
PI: Thombs, Brett D; Benedetti, Andrea
The COVID-19 pandemic has disrupted the lives of people in Canada and across the world due to its rapid spread, number of deaths, toll on health care systems, and devastating economic impact. In addi…
PI: Hazlewood, Glen S; Wells, George A
Rheumatoid arthritis is a chronic autoimmune form of arthritis that can affect adults of any age. People living with rheumatoid arthritis experience pain and swelling in their joints, fatigue, and di…
PI: Choi, May Y
Cardiovascular disease (CVD) remains the most common cause of death in patients with systemic lupus erythematosus (SLE), a multi-system autoimmune disease that disproportionately affects women and yo…
PI: Best, Krista L; Rushton, Paula W; Sheriko, Jordan M
Manual wheelchair (MWC) skills training is a critical component of wheelchair service provision. However, children and youth receive little to no training. Sixteen randomized controlled trials (RCTs)…
PI: Beaule, Paul E; Grammatopoulos, George; Poitras, Stéphane; Wilkin, Geoffrey P
Hip dysplasia is one of the most common causes of hip arthritis. Many patients with hip dysplasia experience years of painful hip symptoms that interfere with activity and quality of life before arth…
PI: Gagnon, Cynthia; Brais, Bernard; Duchesne, Elise; HĂ©bert, Luc J
This study will address the impact of oculopharyngeal dystrophy in the lives of those affected. In addition to dysphagia, our team will document several characteristics related to their physical perf…
HIF1-alpha interacts with MIF to drive inflammation and new bone formation in spondyloarthritis
PI: Haroon, Nigil
Background: Spondyloarthritis (SpA) is a common form of arthritis characterized by inflammation and new bone formation (NBF) in the spine and joint. Patients experience severe pain and restriction in…
PI: Wells, George A; Hazlewood, Glen S; Tugwell, Peter S
Rheumatoid arthritis is a disease that involves inflammation of the joints, tendons, and periarticular structures. It can lead to reduced quality of life and functional limitations. For some patients…